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In This Issue | PNAS
EVOLUTION Radial filament of the netcasting spider Asianopis subrufa, showing an elastomeric core encased by bundles of fine fibers. Architecture of netcasting spider silk The design of polymers typically involves a trade-off between materials that are strong but brittle and materials that are elastic but lacking in strength. Spiders may overcome such inherent limitations by processing silk fibers into composite materials. Jonas Wolff et al.
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function Collin J. Nadarajah, Michelle Y. Li https://orcid.org/0009-0006-0924-9947, Elsa I. Quillin, +10 , Kevin Boyer, Julie M. Dimitry, Yining Chen, Melvin W. King, Ibrahim O. Saliu https://orcid.org/0000-0002-6182-5992, Jiyeon Lee, Patrick W. Sheehan, Albert A. Davis https://orcid.org/0000-0003-2042-8445, Mitchell A.
Large declines in organofluorine contamination indicated by subarctic marine mammal tissues
Large declines in organofluorine contamination indicated by subarctic marine mammal tissues Edited by Catherine Murphy, University of Illinois at Urbana-Champaign, Urbana, IL; received September 5, 2025; accepted November 15, 2025 Significance Detrimental human and wildlife exposures to per- and polyfluoroalkyl substances (PFAS) have prompted shifts in chemical manufacturing toward novel compounds that are difficult to detect.
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