AEs adverse events CI confidence interval HDM house dust mite SABA short-acting beta agonist SLIT sublingual immunotherapy 1 Background Globally, house dust mite (HDM) allergens are contributing factors of persistent allergic rhinitis (AR) and allergic asthma [1, 2]. In children, early sensitisation to HDM is associated with an increased risk of developing HDM allergic asthma, resulting in a high prevalence of asthma among HDM-sensitised children [2, 3].