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Grant M. Barthel on Muck Rack

Grant M. Barthel

As seen in: Nature
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Articles

Benchmarking cell segmentation in two Spatialomics platforms with open-source software

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By Yuyu He, Erin Hudson, Grant M. Barthel, Colleen L. Forster, Kathryn L. Schwertfeger, Thomas Pengo, Mark Sanders, Alessio Giubellino, Andrew Nelson
| Nature Verified
Abstract The in situ tissue microenvironment is a complex mixture of different cell types, microanatomic structures, and acellular matrix material. Further, disease perturbs the morphologies of these features significantly. Spatial proteomics utilizing optical or mass spectrometer imaging simultaneously detects expression and subcellular localization of many proteins.
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Spatial mapping of cellular senescence: emerging challenges and opportunities - Nature Aging

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By Aditi U. Gurkar, Diana Jurk, Elizabeth Thompson, Fei Wu, Fernanda Rodriguez, Grant M. Barthel, Hao Chen, Jeffrey H. Chuang, Jun Lee, Laura J. Niedernhofer, Manoj Kumar, Marta Bueno, Morten Scheibye-Knudsen, Peter Adams, Qianjiang Hu, Rebecca A. Porritt, Timur Khaliullin
| Nature Verified
Abstract Cellular senescence is a well-established driver of aging and age-related diseases. There are many challenges to mapping senescent cells in tissues such as the absence of specific markers and their relatively low abundance and vast heterogeneity. Single-cell technologies have allowed unprecedented characterization of senescence; however, many methodologies fail to provide spatial insights.
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Novel imaging technique captures beauty of metal-labeled neurons in 3-D

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By Karen Thompson, Grant M. Barthel, Karen A. Mesce
| EurekAlert!
Researchers have discovered a dazzling new method of visualizing neurons that promises to benefit neuroscientists and cell biologists alike: by using spectral confocal microscopy to image tissues impregnated with silver or gold.
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