Guangsen Xu on Muck Rack

Guangsen Xu

As seen in: Nature, Wiley Online Library
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Articles

Inhibition of Pellino-1 reverts the progression and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

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By Qian Zhou, Guangsen Xu, Zhuoran Li, Yan Xu, Zhenyu Li, Mingying Li, Tingjian Zu, Yuan Li, Chunhua Lu, Chunyan Ji, Baobing Zhao, Jianmin Guan
| Nature Verified
Abstract BCR-ABL1, derived from structural chromosome rearrangements, is the driver mutation in chronic myeloid leukemia (CML). Targeting BCR-ABL1 for degradation is an ideal therapeutic strategy for CML, however, the regulatory mechanisms controlling BCR-ABL1 expression in CML remained unclear. Here, we identified PELI1 as a key regulator for maintaining BCR-ABL1 in CML.
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Synthesis of 2‐phenylnaphthalenoid amide derivatives and their topoisomerase IIα inhibitory and antiproliferative activities

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By Xiaoxia Wu, Chunhua Lu, Yuemao Shen, Guangsen Xu
| Wiley Online Library Verified
CONFLICTS OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES 1, , , , , , , , , J. Enzyme Inhib. Med. Chem. 2024, 39, 2302320. https://doi.org/10.1080/14756366.2024.2302920 2, , , , Nat. Rev. Mol. Cell Biol. 2022, 23, 407. https://doi.org/10.1038/s41580-022-00452-3 3, , , , Nat. Rev. Mol. Cell Biol. 2016, 17, 703. https://doi.org/10.1038/nrm.2016.111 4, , , Mol. Cell 2012, 45, 710. https://doi.org/10.1016/j.molcel.2012.03.001 5, , , J. Biol. Chem. 2005, 280, 39337.
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