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Guangyuan Li on Muck Rack

Guangyuan Li

New York
As seen in: Medium, Nature, Frontiers, Frontiers in Immunology, MDPI, ACS Publications, Science Magazine, Royal Society of Chemistry, BioRxiv, Cell Press and
Postdoctoral Researcher, Cancer Informatics, New York University
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Articles

Overcoming chemoresistance in esophageal cancer with synergistic strategies

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By Chunxiao Gao, Ting Zhang, Guangyuan Li, Weishan Zhang, Honglin Chen, Jixuan Xu, Mengxue Li, Ruihong Wang, Jian Zhan, Xia Xue, Wulong Liang, Xiangdong Sun, Xiaojuan Zhang, Xinfeng Liang, Zisen Zhang, Xiufeng Chu, Diefei Li, Yamin Xing, Zhentai Ren, Hongqiao Zhan
| Frontiers in Immunology
Abstract Esophageal cancer is a globally prevalent malignancy with poor clinical outcomes. Chemotherapy remains an effective strategy for esophageal cancer. However, its effectiveness is substantially limited by chemoresistance, which arises from both tumor cell adaptation and changes in the surrounding microenvironment. In light of these challenges, combination strategies show great promise for overcoming chemoresistance.
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BMP–Smad1/9 signaling plays a critical role in regulating zebrafish PGC proliferation

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By Tao Zheng, Yaqi Li, Guangyuan Li, Zihang Wei, Jie Li, Zheng Jiang, Roshan Shah, Weiying Zhang, Cencan Xing, Anming Meng, Xiaotong Wu
| Nature Verified
Abstract The germ cell fate in zebrafish is determined by germ plasm, whereas mammalian germ cell fate is induced by bone morphogenetic protein (BMP) signaling. It remains elusive whether BMP signaling is implicated in zebrafish germ cell development. Here, we demonstrate that BMP–Smad1/9 signaling plays a critical role in zebrafish primordial germ cell (PGC) maintenance rather than fate determination. BMP inhibition or smad1/9 knockdown reduces PGC numbers.
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A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice - Nature Immunology

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By Kyle Ferchen, Xuan Zhang, Kairavee Thakkar, Guangyuan Li, Priyanka Rawat, Josh Croteau, Samantha Morris, Harinder Singh, Nathan Salomonis
| Nature Verified
Abstract Large-scale, unbiased single-cell genomics studies of complex developmental compartments, such as hematopoiesis, have inferred novel cell states and trajectories; however, further characterization has been hampered by difficulty isolating cells corresponding to discrete genomic states.
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