Guillaume Bouvier

Abstract The zoonotic pathogen Yersinia pestis, the etiologic agent of plague, has caused three major pandemics and diversified in different lineages currently established in endemic areas worldwide. However, some regions like continental Africa have been poorly covered within the global diversity and epidemiological history of this pathogen. Here, we report the whole-genome sequences of 1,124 Y.

Highlights • A realistic full atom structural description of crosslinkers • An efficient sampling approach to assess protein and linker flexibility • NRGXL performs better than geometrical analysis to predict protein crosslinks Summary Chemical crosslinking, combined with mass spectrometry analysis, is a key source of information for characterizing the structure of large protein assemblies, in the context of molecular modeling.

Guillaume Bouvier† , Catherine Simenel‡, Jichan Jang§∥, Nitin P.