Guolan Lu

Abstract The development of effective antibody therapeutics has been hampered by a lack of methods to measure drug delivery and activity within tumors at single-cell resolution.

Keywords lymph nodes metastasis tumor microenvironment tumor immune evasion spatial context immunomodulation multiplex imaging spatial transcriptomics head-and-neck cancer cancer-associated fibroblasts Introduction Cancer metastasis is a complex, multi-step process that leads to the dissemination of cancer cells from the primary tumor site to distant organs and remains the primary cause of cancer-associated mortality.1 While distant metastases are often preceded by the colonization of...

Abstract Single-cell spatial-omics has advanced our understanding of how tumor microenvironment contributes to cancer progression. However, most single-cell spatial-omics studies focus on cell types and neighborhoods, offering limited information about functional and clinical relevance of cellular organization. We introduce MONTAGE, a computational framework to reconstruct, functionally analyze, and identify clinically relevant cellular spatial communities (SCs).