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Garry P. Nolan on Muck Rack

Garry P. Nolan

Stanford
As seen in: Nature, arXiv, ScienceDirect, Flipboard, Science Magazine, Royal Society of Chemistry, Cell Press, Cell Reports Medicine, Genome Research, Chemistry World and
A world sans hues is a dream yet told. Cancer Bio, Immunology, Bio-Computation, 🏳️‍🌈, UAP/SETI. Negative posters blocked w/o pause.
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Articles

Rewriting the epigenome: CRISPR tools for biological discovery and therapeutics

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By Maximilian Haist, Garry P. Nolan, Sam Reffsin
| ScienceDirect Verified
Rewriting the epigenome: CRISPR tools for biological discovery and therapeutics Author links open overlay panelChristian P. Otero 1 3, Lei S. Qi 2 3 4 Show more The eukaryotic epigenome plays a central role in regulating gene expression, cellular identity, and development through dynamic, multilayered biochemical modifications to DNA, histones, and chromatin architecture.
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Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors

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By Guolan Lu, John Hickey Verified, Maximilian Haist, Xulei Qin, Emily Zhao, Abdullah Naveed, Marc-A. Baertsch, Xavier Rovira-Clave, Andrey Finegersh, Yury Goltsev, Chiara Caraccio, Marisa E. Hom, Brock A. Martin, Christina S. Kong, Natalie Lui, George Fisher, A. Dimitrios Colevas, Robert West, Greg M. Thurber, George A. Poultsides, Garry P. Nolan, Eben Rosenthal, Erna Forgo, Lucas Mani, Nynke S. van den Berg, Deana R. Colburg
| Nature Verified
Abstract The development of effective antibody therapeutics has been hampered by a lack of methods to measure drug delivery and activity within tumors at single-cell resolution.
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CD39 + CD49a + CD103 + cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice

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By Alka Khaitan, David R. Ziehr, PING LIU, Nina Horowitz, Imran MOhammad, June Ho Shin, John Hickey Verified, Peter J. Chockley, Gail Snyder, CHEN CHEN, Keene Lee, Krishna Sharma Verified, Quan Tran, Anahita Nejatfard, Sainiteesh Maddineni, Vasu Divi, Catherine A. Blish, Garry P. Nolan, Jennifer A Foltz, John Sunwoo
| Science Magazine Verified
Editor’s summary Natural killer (NK) cell–based therapies for cancer have shown promise; however, there remains the need to identify the most effective antitumor NK cell subpopulation. Here, Horowitz et al. identified a population of tissue-resident, cytotoxic CD49a+CD103+ NK cells that were distinguishable from their more immunosuppressive counterparts by coexpression of CD39.
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