Garry P. Nolan on Muck Rack

Garry P. Nolan

Stanford
As seen in: Nature, Flipboard, Science Magazine, Royal Society of Chemistry, Cell Press, Cell Reports Medicine, Genome Research, Chemistry World, The Journal of Immunology, Anchor.fm
A world sans hues is a dream yet told. Cancer Bio, Immunology, Bio-Computation, 🏳️‍🌈, UAP/SETI. Negative posters blocked w/o pause.
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Articles

Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors

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By Guolan Lu, John Hickey Verified, Maximilian Haist, Xulei Qin, Emily Zhao, Abdullah Naveed, Marc-A. Baertsch, Xavier Rovira-Clave, Andrey Finegersh, Yury Goltsev, Chiara Caraccio, Marisa E. Hom, Brock A. Martin, Christina S. Kong, Natalie Lui, George Fisher, A. Dimitrios Colevas, Robert West, Greg M. Thurber, George A. Poultsides, Garry P. Nolan, Eben Rosenthal, Erna Forgo, Lucas Mani, Nynke S. van den Berg, Deana R. Colburg
| Nature Verified
Abstract The development of effective antibody therapeutics has been hampered by a lack of methods to measure drug delivery and activity within tumors at single-cell resolution.
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CD39 + CD49a + CD103 + cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice

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By Alka Khaitan, David R. Ziehr, PING LIU, Nina Horowitz, Imran MOhammad, June Ho Shin, John Hickey Verified, Peter J. Chockley, Gail Snyder, CHEN CHEN, Keene Lee, Krishna Sharma Verified, Quan Tran, Anahita Nejatfard, Sainiteesh Maddineni, Vasu Divi, Catherine A. Blish, Garry P. Nolan, Jennifer A Foltz, John Sunwoo
| Science Magazine Verified
Editor’s summary Natural killer (NK) cell–based therapies for cancer have shown promise; however, there remains the need to identify the most effective antitumor NK cell subpopulation. Here, Horowitz et al. identified a population of tissue-resident, cytotoxic CD49a+CD103+ NK cells that were distinguishable from their more immunosuppressive counterparts by coexpression of CD39.
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Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment

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By Yao Yu Yeo, Huaying Qiu, Yunhao Bai, Bokai Zhu, Yuzhou Chang, Fabio Iannelli, Jason Yeung, Hendrik A Michel, Yuchen Wang, Yang Wang, Wenrui Wu, Kyle Wright, Muhammad Shaban, Sam Sadigh, Dingani Nkosi, Vignesh Shanmugam, Philip Rock, Julia Paczkowska, Pierre Stéphan, Guanrui Liao, Amy Huang, Hongbo Wang, Han Chen, Leonie Frauenfeld, Louisa Kaufmann, Stefano A Pileri, Bidisha Mitra Verified, Benjamin E. Gewurz, Bo Zhao, Garry P. Nolan, Baochun Zhang, Alex K. Shalek, Michael Angelo, Christian M. Schürch, Faisal Mahmood, Roberto Chiarle, Qin Ma, W. Richard Burack, Margaret A. Shipp, Scott J. Rodig, Sizun Jiang, Precious Cramer
| Cell Reports Medicine Verified
Keywords multiplexed imaging spatial proteomics spatial transcriptomics EBV tumor virus tumor microenvironment Hodgkin lymphoma systems immunology Introduction Classic Hodgkin lymphoma (cHL) is a B cell lymphoid malignancy that most frequently occurs in young adults and less commonly in the elderly.1 The cHL tumor microenvironment (TME) has unique features, including rare malignant Hodgkin and Reed-Sternberg (HRS) multinucleated cells (comprising 1%–5% of the cHL TME cell composition) nested...
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