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Articles by Guoping Chen
Revealing the spatiotemporal evolutionary trajectories of multi-scale territorial spatial conflicts in Yunnan: an interpretable and causal machine learning framework
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. Abstract Clarifying how Territorial Spatial Conflicts (TSC) evolve across space and time is fundamental to understanding the internal dynamics of territorial spatial systems and to advancing more effective regional spatial governance.
A single-cell atlas of the human respiratory system identifies a monocyte-centered HSPA1B + inflammatory primed state associated with WTAP
Abstract Chronic obstructive pulmonary disease (COPD) is characterized by persistent pulmonary inflammation and tissue remodeling, yet the cellular states and regulatory mechanisms underlying monocyte functional heterogeneity remain incompletely understood. Here, we generate a high-resolution single-cell transcriptomic atlas of the human respiratory system and identify a diverse monocyte functional landscape in healthy lungs containing a HSPA1B+ inflammatory monocytes state.
High-Resolution Molecular Analyses Reveal Non-additive Impacts of Chronic Warming and Nitrogen Addition on Soil-Derived Dissolved Organic Matter Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Dissolved organic matter (DOM) plays a central role in soil carbon (C) cycling as the most mobile and reactive C fraction in forests, regulating the microbial metabolism, nutrient availability, and C export. However, molecular-level DOM responses to environmental stressors such as warming and nitrogen (N) deposition remain poorly constrained, particularly under their combined influences.
Robust Risk Assessment for Park-Level Integrated Energy Systems: A Framework for Adaptive Governance under Deep Uncertainty
Practical Applications Industrial park planners, energy investors, and policymakers face a critical challenge: how to choose the right energy system when future technologies, costs, and regulations are highly uncertain. Selecting the wrong path can lead to costly, long-term mistakes. This research provides a practical, evidence-based decision-support framework to navigate this uncertainty. The proposed tool moves beyond simple “best versus worst” rankings.
Successful rapid desensitization to multiple insulin preparations in an adult with type 1 diabetes: a case report and literature review
CASE REPORT article Volume 17 - 2026 | https://doi.org/10.3389/fendo.2026.1715012 This article is part of the Research TopicThe role of delabelling and immunotherapy techniques: Advancements in allergy managementView all articles 1 Introduction Insulin allergy, though uncommon since the advent of recombinant human insulin (estimated prevalence ~2%) (1), remains a serious clinical concern.
Precision‐Engineered Silver Single‐Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury
1 Introduction Overproduction of reactive oxygen species (ROS) is an important pathological feature of many diseases, including acute kidney injury (AKI), a critical clinical syndrome characterized by the sudden loss of renal function and high mortality [1, 2].
Spatiotemporal Variation of Vegetation Greenness and Its Response to Extreme Climate Events: A Case Study of the Central Yunnan Urban Agglomeration, China
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References , , , et al. 2021. “A Unified Vegetation Index for Quantifying the Terrestrial Biosphere.” Science Advances 7, no. 9: eabc7447. https://doi.org/10.1126/sciadv.abc7447. , , , et al. 2025.
Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine
1 Introduction Immunotherapies, including cancer vaccines, immune cell activation, and immune checkpoint blockade, have become a mainstay in the treatment of various cancers.[1] The immune system comprises innate and adaptive systems,[2] and the capacity of these systems to interact with each other is crucial for enhancing the human immune system's cytotoxic effects in malignancy treatment.[3] Tumor-derived cyclic GMP-AMP synthase (cGAS) triggers the stimulator of interferon genes (STING)...
Understanding Self‐Perceived and Other‐Perceived Body Image in Adolescents: The Roles of Neuroticism, Mindfulness, and Self‐Compassion
Conflicts of Interest The authors declare no conflicts of interest. References , and . 2020. “Personality and Body Dissatisfaction: An Updated Systematic Review With Meta-Analysis.” Body Image 33: 77–89. https://doi.org/10.1016/j.bodyim.2020.02.001. , and . 2016. “Personality and Body Image: A Systematic Review.” Body Image 19: 79–88. https://doi.org/10.1016/j.bodyim.2016.08.012. , and . 2016.
Multi-scale Decomposition and Hybrid Deep Learning CEEMDAN-VMD-CNN-BiLSTM Approach for Wind Power Forecasting
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Temporal and Spatial Carbon Stock Changes and Driving Mechanisms Based on Land Use Multi‐Scenario Modeling: An Assessment of SDGs15.3—A Case Study of the Central Yunnan Urban Agglomeration, China
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description ldr5548-sup-0001-supinfo.docxWord 2007 document , 270.2 KB Data S1. Supporting Information. References , and . 2024. “Spatiotemporal Variation of Vegetation Carbon Stocks and Its Driving Factors in the Urumqi River Basin.” Ecological Indicators 159: 111668. https://doi.org/10.1016/j.ecolind.2024.111668. , , , and . 2018.
Spatiotemporal Characteristics and Scale Effects of Ecosystem Service Bundles in the Xijiang River Basin: Implications for Territorial Spatial Planning and Sustainable Land Management
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Ecological Network Optimization and Ecological Security Pattern Construction for Kunming's Main Urban Area Based on the MSPA-MCR Model
Submitted: 21 February 2025 You are already at the latest version Rapid urbanization has greatly altered urban ecological spaces and habitat quality functions, threatening regional biodiversity and the sustainability of landscapes. Therefore, constructing a comprehensive ecological network and ecological safety patterns is crucial for ecosystem management and regional development.
High-Capacity Testing System Based on Power System Supply
Submitted: 18 February 2025 You are already at the latest version With the expansion of power system scale and the advancement of new energy grid integration, the performance verification of medium and high-voltage power equipment faces increasingly stringent requirements.
Enhancing Photocatalytic Hydrogen Evolution with Oxygen Vacancy-Modified P/Ag/Ag2O/Ag3PO4/TiO2 by Using Optimized NaBH4 Reduction Strategy
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Mobile Phone Addiction, Self‐Control, Mind Wandering, and Cognitive Failure in Chinese Adolescents: A Network Analysis and a Chain Mediation Model
Supporting Information Filename Description pits23426-sup-0001-Supplementary_Materials.docx2.3 MB Supporting information. References , , , , , and . 2024. “Do Smartphone Addiction and Self-Regulation Failures Affect Students’ Academic Life Satisfaction? The Role of Students’ Mind Wandering and Cognitive Failures.” Psychology Research and Behavior Management 17: 1231–1253. https://doi.org/10.2147/prbm.s437076. , , , and . 1998.
Effect of microenvironmental viscosity on the emergence of colon cancer cell resistance to doxorubicin
Effect of microenvironmental viscosity on the emergence of colon cancer cell resistance to doxorubicin Colon possesses a unique physiological environment among human organs, where there is a highly viscous body fluid layer called mucus layer above colonic epithelial cells. Dysfunction of the mucus layer not only contributes to the occurrence of colorectal cancer (CRC) but also plays an important role in the development of chemoresistance in CRC.
Influence of viscosity on adipogenic and osteogenic differentiation of mesenchymal stem cells during 2D culture
Influence of viscosity on adipogenic and osteogenic differentiation of mesenchymal stem cells during 2D culture Accumulatively, cellular behaviours triggered by biochemical cues have been widely explored, and the focus of research is gradually shifting to biophysical cues. Compared to physical parameters such as stiffness, substrate morphology, and viscoelasticity, the influence of viscosity on cellular behaviours is relatively unexplored and overlooked.
Pentagon‐Rich Caged Carbon Catalyst for the Oxygen Reduction Reaction in Acidic Electrolytes
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Pentagon‐Rich Caged Carbon Catalyst for the Oxygen Reduction Reaction in Acidic Electrolytes
Introduction Carbon materials are highly anticipated as electrode catalysts that will be used in large quantities in a carbon-neutral society.
Forests | Free Full-Text | Revealing the Nonlinear Impact of Human Activities and Climate Change on Ecosystem Services in the Karst Region of Southeastern Yunnan Using the XGBoost-SHAP Model
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Coupling and Coordination Relationship of Economic-Social-Natural Composite Ecosystem in Central Yunnan Urban Agglomeration
1. Introduction Social, economic, and natural elements together constitute a composite ecosystem on which human beings depend for their survival and development []. The three subsystems are interconnected through the flow of energy, matter, and information to form a higher level coupled system []. The report of the 20th National Congress of the Communist Party of China explicitly stated that one of the essences of Chinese-style modernization is the harmonious coexistence between humans and nature.
Coupling and Coordination Relationship of Social-Economic-Natural Composite Ecosystem in Central Yunnan Urban Agglomeration
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 23 January 2024 / Approved: 24 January 2024 / Online: 25 January 2024 (01:51:08 CET) Yang, A.; Zhao, J.; Lin, Y.; Chen, G. Coupling and Coordination Relationship of Social-Economic-Natural Composite Ecosystem in Central Yunnan Urban Agglomeration. Preprints 2024, 2024011763. https://doi.org/10.20944/preprints202401.1763.v1 Yang, A.; Zhao, J.; Lin, Y.; Chen, G.
Lixisenatide ameliorated lipopolysaccharide (LPS)‐induced expression of mucin and inflammation in bronchial epithelial cells
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , , Am. J. Physiol. Lung Cell. Mol. Physiol. 2020, 319, L879. 2, , , , , Int. J. Chronic Obstruct. Pulm. Dis. 2018, 13, 1353. 3, , , Respirology 2015, 20, 1160. 4, , N. Engl. J. Med. 2015, 373, 185. 5, , Eur. Respir. J. 2019, 54, 1900651. 6, , , , , , , , , , , , , , , , Am. J. Physiol. Lung Cell. Mol. Physiol. 2021, 320, L73. 7, , , , Inflamm Res. 2022, 71, 797. 8, Eur. Respir. J. 2020, 55, 1902473.
Research on Secure Storage Technology of Spatiotemporal Big Data Based on Blockchain
Open AccessArticle by 1,2,3,4, 1,2,3,4,*, 1,2,3,4 and 5 1 Faculty of Land Resources Engineering, Kunming University of Science and Technology, Kunming 650093, China 2 Key Laboratory of Geospatial Information Integration Innovation for Smart Mines, Kunming 650093, China 3 Spatial Information Integration Technology of Natural Resources in Universities of Yunnan Province, Kunming 650211, China 4 The Industry-University-Research Integration Innovation Base of Natural Resources Smart Management,...
Elevational Patterns of Tree Species Richness and Forest Biomass on Two Subtropical Mountains in China
Abstract : Increasing evidence shows that both abiotic and biotic factors affect species richness and stand biomass in forests, yet the relative and interactive impacts of these factors remain debated in different forest ecosystems.
Security Authentication Mechanism of Spatio-Temporal Big Data Based on Blockchain
Abstract : Spatiotemporal big data are a kind of data that marks time information and geographic location and has been widely applied in various fields. However, there are always security issues with spatiotemporal big data, especially in data collection and authentication. Traditional authentication protocols are less efficient in the face of ultra-large-scale IoT (Internet of Things, IoT) device verification, and the threat of single-point failure is relatively large.
Cholesterol induces inflammation and reduces glucose utilization
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Spatial Coupling of Carbon Sink Capacity with High-Quality Development Based on Exploitation and Protection Pattern
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Landslide Susceptibility Evaluation of Machine Learning Based on Information Volume and Frequency Ratio: A Case Study of Weixin County, China
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Coupling PLUS–InVEST Model for Ecosystem Service Research in Yunnan Province, China
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Transcription and Metabolism Pathways of Anthocyanin in Purple Shamrock (Oxalis triangularis A.St.-Hil.)
Open AccessArticle by Baobing Luo 1, Liujun Chen 1, Guoping Chen 1, Yunshu Wang 1, Qiaoli Xie 1, Xuqing Chen 2,* and Zongli Hu 1,* 1 Laboratory of Molecular Biology of Tomato, Bioengineering College, Chongqing University, Chongqing 400044, China 2 Institute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China * Authors to whom correspondence should be addressed.
Land Change Simulation and Forest Carbon Storage of Central Yunnan Urban Agglomeration, China Based on SSP-RCP Scenarios
Abstract : Land use change is closely related to the terrestrial ecosystem. Studying the relationship between land use and ecosystem service carbon storage under future climate change can optimize the regional ecosystem service function and formulate sustainable social and economic development policies, which is of great significance for regional carbon emission management and climate change response.
Introduction to New era in advanced functional materials emerging from molecular imprinting and related techniques
Introduction to New era in advanced functional materials emerging from molecular imprinting and related techniques Karsten Haupt, a Toshifumi Takeuchi †b and Guoping Chen c Abstract A graphical abstract is available for this content You have access to this article Please wait while we load your content... Something went wrong. Try again? Article information Article type Editorial First published 07 Sep 2022 Download Citation J. Mater. Chem.
New era in advanced functional materials emerging from molecular imprinting and related techniques Home
About this collection Recent developments in molecular imprinting and related technologies have attracted a great deal of attention in the field of materials science. Many scientists and engineers in academia and industry, in the analytical, biomedical, environmental and materials sciences are interested in molecularly imprinted polymers (MIPs).
Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis
Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis† Pei Li, a Guoping Chen,a Jiaxian Zhang,a Chaoying Pei,a Ying Chen,a Jing Gong,a Song Deng,a Kaiwei Cai,a Haiyan Li,a Dawei Wang,b Baochun Shen,c Zhiyong Xie *d and Qiongfeng Liao *a Author affiliations * Corresponding authors a School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China E-mail: Zyfxliao@Gzucm.Edu.Cn b ShunDe Hospital GuangZhou...
Outcomes of fluoroscopy-guided percutaneous high ligation of the great saphenous vein combined with foam sclerotherapy for symptomatic great saphenous veins
This paper is only available as a PDF. To read, Please Download here. Highlights This study is to evaluate the effectiveness and safety of the fluoroscopy-guided percutaneous high ligation (FPHL) combined with fluoroscopy-guided foam sclerotherapy (FGFS) to treat great saphenous varicose (GSV). The FPHL combined FGFS is a relatively new technique which could ligate the GSV without large surgical incision.
Dapagliflozin Reduces Urinary Albumin Excretion by Downregulating the Expression of cAMP, MAPK, and cGMP-PKG Signaling Pathways Associated Genes
Introduction Albuminuria, declining glomerular filtration rate (GFR), and arterial hypertension are symptoms of diabetic nephropathy (DN), which affects 20–40% of patients with type 1 and type 2 diabetes (Muskiet et al., 2019). DN clinically manifests as macrovascular and microvascular complications, which are the most common causes of end-stage renal disease (ESRD) (Flyvbjerg, 2017). The molecular mechanisms underlying DN remain unclear.
Chemical Looping Combustion of Coal Chars Using Iron Ore of Different Grades as Oxygen Carriers
Natural ore, which is cost-effective and reserve-abundant, is more attractive to be used as oxygen carriers (OCs) in industrial-scale chemical looping combustion (CLC) units compared to synthetic OCs. In this paper, five kinds of iron ore of different grades (with Fe2O3 contents at around 50, 60, 70, 80, and 90 wt %) are investigated as OCs in a batch fluidized bed reactor by using three kinds of coal char with different ranks as fuels.
Journal of Materials Chemistry B and Biomaterials Science Editor's choice web collection: “Recent advances in microfluidics”
Journal of Materials Chemistry B and Biomaterials Science Editor's choice web collection: “Recent advances in microfluidics” You have access to this article Please wait while we load your content... Something went wrong. Try again?
Fabrication of gelatin-micropatterned surface and its effect on osteogenic differentiation of hMSCs
Studies of the effect of surface chemistries on cell functions on one surface with different surface chemistry areas have been achieved by micropatterning technology. In this study, gelatin-micropatterned surface was prepared and used for directly comparing the effect of different surface chemistry on the osteogenic differentiation of stem cells under the same culture environment.
Dynamic Analysis of Planar Mechanical Systems With Clearance Joint Based on LuGre Friction Model
A computational methodology to model and analyze planar rigid mechanical system with stick–slip friction in revolute clearance joint is presented. In this work, the LuGre friction model, which captures the Stribeck effect and spring-like characteristics for stiction, is employed to estimate the stick–slip friction in revolute clearance joint. A hybrid contact force model, combining Lankarani–Nikravesh model, and improved elastic foundation model, is used to establish contact model.
Preparation of dexamethasone-loaded calcium phosphate nanoparticles for osteogenic differentiation of human mesenchymal stem cells
As an earliest known and readily available osteogenic inducer for stem cells, dexamethasone (DEX) plays a key role in affecting cell functions and cellular processes, especially for cell proliferation and differentiation. However, the clinical application of DEX has been limited because of its uncontrolled release. An ideal carrier is desired to control DEX release for osteogenic differentiation of stem cells and bone tissue engineering.
Influence of microporous gelatin hydrogels on chondrocyte functions
Hydrogels can provide biomimetic three-dimensional microenvironments for transplanted cells and are attractive scaffolds for cartilage tissue engineering. In this study, gelatin hydrogels with microporous structures were prepared and their effects on chondrocyte functions were compared with gelatin hydrogels without microporous structures. Gelatin bulk hydrogels were prepared by photo-initiated crosslinking of gelatin methacrylate macromers.
Sub-10 nm gold nanoparticles promote adipogenesis and inhibit osteogenesis of mesenchymal stem cells
Sub-10 nm gold nanoparticles (Au NPs) have attracted extensive attention for different biomedical applications because of their small size. However, the influence of small NPs on differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) is unclear. In this study, 4-nm small Au NPs (Au4-mPEG NPs) were synthesized to investigate their influence on osteogenic and adipogenic differentiation of hMSCs with 40-nm counterparts (Au40-mPEG NPs) as a comparison.
Insight into the interactions between nanoparticles and cells
Multifunctional nanoparticles (NPs) have been widely used in biomedical applications because of their versatile properties. The properties of NPs should be well designed and controlled according to various applications because they may directly affect the functions and performances of NPs in biological systems. Cellular uptake is a prerequisite for the success of NP-based biomedical applications. However, the internalized NPs inside cells may have some adverse effects.
Composite scaffolds of gelatin and gold nanoparticles with tunable size and shape for photothermal cancer therapy
Photothermal therapy (PTT) has been extensively investigated as a promising strategy for cancer therapy. For successful application of this technique, various nanomaterials have been explored as photothermal conversion agents. Gold nanoparticles (AuNPs), especially Au nanorods and Au nanostars, have received much attention for photothermal therapy because of their facile preparation and high photothermal conversion efficiency.
Composite scaffolds of gelatin and gold nanoparticles with tunable size and shape for photothermal cancer therapy
Photothermal therapy (PTT) has been extensively investigated as a promising strategy for cancer therapy. For successful application of this technique, various nanomaterials have been explored as photothermal conversion agents. Gold nanoparticles (AuNPs), especially Au nanorods and Au nanostars have received much attention for photothermal therapy because of their facile preparation and high photothermal conversion efficiency.
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