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Kachaporn Jintana on Muck Rack

Kachaporn Jintana

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Articles

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

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By Idalba Serrato-Pomar, Hacène Medkour, Lauryne Pruvost, Norman Schneider, Mihra Tavadia, Jim Zoladek, Florian Rachenne, Quentin Narpon, Félix Rey-Cadilhac, Stephanie French, Cassandra M Modahl, Carole Ginibre, Wannapa Sornjai, Elliott F. Miot, Duncan Smith, Rodolphe Hamel, Dorothée Missé, Sébastien Nisole, Julien Pompon, Louise Belleville, Kachaporn Jintana, Zoé Roux, Solena Rossi, Bethsabée Scheid, Oleg Medianikov
| Nature Verified
Abstract Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Skin infection at the bite site represents a critical and conserved step in transmission and a deeper understanding of this process will promote the design of broad-spectrum interventions. Here, we identify and characterize a transmission-enhancing viral factor in mosquito saliva that is shared across orthoflaviviruses.
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