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Haiming Wei on Muck Rack

Haiming Wei

As seen in: Nature, Wiley Online Library, Frontiers, MDPI, Genome Medicine, Cell Press, Cell Reports, The Journal of Immunology
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Articles

Histone lactylation-driven intratumoral IGFBP2 + NK cells promote tumor immune evasion

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By Xuben Wang, Zhuanghao Hou, Qikai Sun, Quanwei Cui, Guirong Shi, Xianghui Du, Ji Liu, Yeben Qian, Guangming Huang, Rongbin Zhou, Zhigang Tian, Haoyu Sun, Haiming Wei, Hongdi Ma, Xiaohu Zheng, Zhigang Nian
| Cell Reports Verified
Keywords natural killer cell insulin-like growth factor binding protein 2 liver cancer histone lactylation immune checkpoint-targeted therapy Research topic(s) CP: immunology CP: cancer Introduction Natural killer (NK) cells are pivotal innate immune effectors capable of directly targeting and killing tumor cells or infected cells through cytotoxic mechanisms and the release of proinflammatory cytokines.1,2,3 Moreover, NK cells exhibit regulatory functions, modulating adaptive immune...
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Proinflammatory monocyte-derived granulocyte-macrophage colony-stimulating factor fuels airway inflammation in bronchopulmonary dysplasia

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By Shushu Wang, Xuesong Wang, Dongyao Wang, Binqing Fu, Mingwu Chen, Yong Lv, Huiru Wang, Yonggang Zhou, Haiming Wei, Haoquan Zhou
| Nature Verified
Abstract Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity and long-term respiratory complications in preterm neonates. Effective strategies for moderate-severe BPD are currently lacking. Tracheal aspirate (TA) samples were collected from 62 preterm neonates, and the immune cell composition was analyzed using multicolor flow cytometry. Subsequently, CD14+ monocytes were isolated and purified from the TA samples for transcriptomic sequencing analysis.
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Dipeptidylpeptidase 4 inhibition attenuates gestational pathologies via immune homeostasis restoration in the pulmonary-uterine axis - Nature Communications

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By Guirong Shi, Shengdi Xi, Mengyuan Lv, Yihang Chen, Yonggang Zhou, Haiming Wei, Binqing Fu
| Nature Verified
Abstract Respiratory viral infections during pregnancy threaten maternal pulmonary health and fetal development, however the mechanisms linking lung infection to distant uterine immune disruption remain unclear. Here, we demonstrate that respiratory viral infection attenuates uterine immune activation, impairing vascular remodeling and trophoblast invasion, which compromises embryonic growth.
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