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Haisam Alattar

As seen in: Wiley Online Library, MDPI, BioRxiv, Cell Press
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Articles

A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer

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By Greta Mattavelli, Moutaz Helal, Ana Cetkovic, Maximilian Kramer, Saskia-Laureen Herbert, Kilian Mielert, Tanja Schlaiß, Anna Frank, Emily Riemer, Mara John, Josefina del Pilar, Martínez Vásquez, Laura Kindl, Jonathan J. Swietlik, Benedikt O. Gansen, Hanna K. Fischer, Jonas Bauer, Arpa Aintablian, Haisam Alattar, Manfred Lütz, Felix Meissner, Thordur Aegir Oskarsson, Leo Rasche, Gustavo Melo Ramos, Andreas Rosenwald, Achim Wöckel, Angela Riedel, Marion Krafft, Emilia Stanojkovska, Ute-Susann Albert, Murilo Delgobo
| Cell Press Verified
Keywords tumor-draining lymph node fibroblastic reticular cells triple-negative breast cancer metastasis pre-metastatic niche immunosuppressive monocytes immunotherapy single-cell sequencing spatial transcriptomics tumor microenvironment Introduction Triple-negative breast cancer (TNBC) is characterized by higher risks of relapse or metastatic disease and a poor 5-year survival in comparison with other breast cancer (BC) subtypes.1 Neoadjuvant immune checkpoint blockade (ICB) in combination...
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AMPK Activation Downregulates TXNIP, Rab5, and Rab7 Within Minutes, Thereby Inhibiting the Endocytosis-Mediated Entry of Human Pathogenic Viruses

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By Viktoria Diesendorf, Veronica La Rocca, Michelle Teutsch, Haisam Alattar
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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MDSC depletion during immunization with heat-killed Mycobacterium tuberculosis increases protection against BCG infection.

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By Haisam Alattar, Laura Cyran, Christoph Schoen, Arpa Aintablian
| BioRxiv
Abstract Tuberculosis (TB) is still one of the deadliest infectious diseases globally. Although i.d. BCG immunization offers limited protection, a vaccine based on Mycobacterium tuberculosis (Mtb) has yet to be approved. Our previous findings demonstrated that s.c. immunization with heat-killed Mtb significantly increased the number of monocytic myeloid-derived suppressor cells (M-MDSC) in mice.
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