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Kilian Mielert

As seen in: Cell Press
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Articles

A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer

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By Greta Mattavelli, Moutaz Helal, Ana Cetkovic, Maximilian Kramer, Saskia-Laureen Herbert, Kilian Mielert, Tanja Schlaiß, Anna Frank, Emily Riemer, Mara John, Josefina del Pilar, Martínez Vásquez, Laura Kindl, Jonathan J. Swietlik, Benedikt O. Gansen, Hanna K. Fischer, Jonas Bauer, Arpa Aintablian, Haisam Alattar, Manfred Lütz, Felix Meissner, Thordur Aegir Oskarsson, Leo Rasche, Gustavo Melo Ramos, Andreas Rosenwald, Achim Wöckel, Angela Riedel, Marion Krafft, Emilia Stanojkovska, Ute-Susann Albert, Murilo Delgobo
| Cell Press Verified
Keywords tumor-draining lymph node fibroblastic reticular cells triple-negative breast cancer metastasis pre-metastatic niche immunosuppressive monocytes immunotherapy single-cell sequencing spatial transcriptomics tumor microenvironment Introduction Triple-negative breast cancer (TNBC) is characterized by higher risks of relapse or metastatic disease and a poor 5-year survival in comparison with other breast cancer (BC) subtypes.1 Neoadjuvant immune checkpoint blockade (ICB) in combination...
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