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Haojie Yu on Muck Rack

Haojie Yu

As seen in: Nature, Wiley Online Library, PLOS, MDPI, BMC Genomics, Royal Society of Chemistry, BioRxiv, Cell Press, Journal of Sensors
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Articles

CuAgent provides a RAG-assisted intelligent framework to investigate cuproptosis

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By Chunlong Zhang, Jin Bao, Haojie Yu, Xuecang Li, Jianli Ma, Ning Zhao, Haijie Cui
| Nature Verified
Abstract Cuproptosis is a novel form of regulated cell death driven by intracellular copper accumulation, leading to lipoylated protein aggregation and Fe-S cluster destabilization. Dysregulation of this process has been implicated in various pathological conditions, including cancers, neurodegenerative diseases and metabolic diseases.
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pH-Dependent Behavior of Ru-Based Hydrogen-Oxidation Electrocatalysis by a Reconstructed Hydrogen-Bond Network

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By Lixin Su, Chenxi Cui, Haojie Yu
| Wiley Online Library Verified
L.Su, C.Cui, and H.Yu, et al., Angewandte Chemie International Edition ((2026), e8831785, https://doi.org/10.1002/anie.8831785 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the Supporting Information of this article.
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GPR146 in adipose tissue drives adipose-liver crosstalk and promotes hepatic steatosis in mice - Nature Communications

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By Yu Shi, Thi Thi, Yifan Wang Verified, Xiaoyun Cao, Vanna Chhay, Yujia Shen, Yuchen He, Tianyun Zhao, Amy Deik, Courtney Dennis, Kerry A. Pierce, Kevin Bullock, Martin Wabitsch, Clary B. Clish, Alexander Banks, Radoslaw M. Sobota, Chad A. Cowan, Haojie Yu
| Nature Verified
Abstract The limited therapeutic options for metabolic dysfunction-associated steatotic liver disease (MASLD) underscore the need for deeper mechanistic insight and new treatment strategies. Here, we identify the orphan G protein-coupled receptor GPR146 as a regulator of hepatic steatosis through adipose–liver crosstalk. Human genetic analyses link the GPR146 locus to circulating markers of liver injury and inflammation.
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