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Haoting Sun

As seen in: Nature, Wiley Online Library
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Articles by Haoting Sun

mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formation

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By Tiantian Zou, Xufeng Wang, Haoting Sun, Beiyuan Hu, Jianhua Li, Yu Guo, Zilu Tian, Hao Xu, Yan Zheng, Le Zhu, Keyu Shen, Xiaotian Shen, Qiongzhu Dong, Lun-Xiu Qin, Yinghan Su, Chak Lam Chan
| Nature Verified
Abstract Tumor-derived extracellular vesicles (EVs) play crucial roles in facilitating the colonization and growth of metastatic cancer cells in distant organs. Nevertheless, the precise mechanisms by which EVs contribute to therapy-resistant cancer dissemination remain poorly understood.
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Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

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By Yingxue Li, Wei Zhang, Changxiang Huan, Haoting Sun
| Wiley Online Library Verified
1 Introduction Hepatocellular carcinoma (HCC), the most common histological subtype of liver cancer, is the third-leading cause of cancer-related death worldwide.[1] Although patients with resectable HCC can be treated with surgical resection or liver transplantation, and patients with advanced unresectable HCC can be treated with sorafenib, these tumors are prone to recurrence after treatment.[2] Despite advances in immune checkpoint blockade (ICB) therapy, such as anti-PD-1/L1 antibodies,...
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