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Harshil Patel

As seen in: Medium, MSN, MSN Ireland, MSN UK, Nature, PLOS, PLOS Biology, Yahoo Finance UK, BMJ Open, MDPI and
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Articles

Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity

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By Sandra Segura-Bayona, Marija Maric, Tohru Takaki, Tyler H. Stanage, Aurora I. Idilli, Shudong Li, Graeme Hewitt, Feras E. Machour, Rhona Millar, Marek Adamowicz, Phil Ruis, Benura Azeroglu, Todd Fallesen, Harshil Patel, Steven Howell, Panagiotis Kotsantis, Michael Howell, Simon J. Boulton, Zornitsa Manova
| Nature Verified
Abstract Mutations in the ATRX chromatin remodeler confer a predisposition to a developmental genetic disorder and cancer, but how ATRX safeguards genome and telomere stability remains unresolved. Here, we uncover critical dependencies for the CTC1–STN1–TEN1 (CST) complex and RAD9A–HUS1–RAD1 (9-1-1) clamp in ATRX-deficient cells. ATRX–CST synthetic lethality manifests following accumulation of telomeric G-rich single-stranded DNA (ssDNA), which results in telomere loss and cell death.
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How to turn a £20k ISA into a £12,000 yearly second income Original

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By Harshil Patel
| twelfthmagpie.com
One of my goals is to eventually turn my ISA investments into a reliable second income. Currently, my portfolio is in a growth phase, so I’m reinvesting dividends and focusing on earnings and dividend growth. But one day, I’ll switch my strategy to maximise dividends and passive income. Now, an investor with £20,000 isn’t starting with a life-changing sum of money.
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How an £18,472 passive income portfolio could generate £1,108 a year in extra cash Original

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By Harshil Patel
| twelfthmagpie.com
For a full-time worker in their 50s, building a passive income stream before retirement might be easier than first thought. In fact, a £18,472 investment portfolio generating a 6% yield could produce around £1,108 a year in extra cash. Better still, if those dividends are reinvested over time, the income could grow significantly. Let’s crunch some numbers. That £1,108 could buy more shares to add to the total pot. Each of these new shares also pay a dividend.
Open in Who Shared View Duplicates (3) Issue with article?
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