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Michael Howell on Muck Rack

Michael Howell

As seen in: Nature, JAMA: Journal of the American Medical Association, Cell Press, Stem Cell Reports, WJLA-TV (Arlington, VA), HIT Consultant, The Journal of Allergy & Clinical Immunology, Journal of The American Academy of Dermatology (JAAD), SKIN The Journal of Cutaneous Medicine, Saltscapes Magazine
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Articles

Losing sleep over glia: new mechanisms for Alzheimer-related sleep disruption

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By Brendan P. Lucey, Michael Howell
| Nature Verified
Sleep disruption in Alzheimer disease has long been viewed as a downstream consequence of amyloid and tau. Two new studies show that glia-mediated mechanisms involving microglia and astrocytic aquaporin 4, rather than amyloid plaque burden, disrupt sleep and are potential targets to prevent Alzheimer disease-related sleep loss.
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Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity

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By Sandra Segura-Bayona, Marija Maric, Tohru Takaki, Tyler H. Stanage, Aurora I. Idilli, Shudong Li, Graeme Hewitt, Feras E. Machour, Rhona Millar, Marek Adamowicz, Phil Ruis, Benura Azeroglu, Todd Fallesen, Harshil Patel, Steven Howell, Panagiotis Kotsantis, Michael Howell, Simon J. Boulton, Zornitsa Manova
| Nature Verified
Abstract Mutations in the ATRX chromatin remodeler confer a predisposition to a developmental genetic disorder and cancer, but how ATRX safeguards genome and telomere stability remains unresolved. Here, we uncover critical dependencies for the CTC1–STN1–TEN1 (CST) complex and RAD9A–HUS1–RAD1 (9-1-1) clamp in ATRX-deficient cells. ATRX–CST synthetic lethality manifests following accumulation of telomeric G-rich single-stranded DNA (ssDNA), which results in telomere loss and cell death.
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Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes

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By Hannah Franklin, Hamish Crerar, Nishita Parnandi, Stanislaw Majewski, Benjamin Clarke, Husayn Pallikonda, Michael Howell, Simon J. Boulton, Rickie Patani, Michael Lattke
| Stem Cell Reports Verified
ArticleOnline now102723Open access 1The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK 2Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK 3Department of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK 4Neurobiology Programme, Life Sciences Institute, Centre for Life Sciences, National University of Singapore, Singapore, Singapore 5Department of Medicine, Yong Loo Lin School of...
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