Zornitsa Manova on Muck Rack

Zornitsa Manova

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Articles

Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity

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By Sandra Segura-Bayona, Marija Maric, Tohru Takaki, Tyler H. Stanage, Aurora I. Idilli, Shudong Li, Graeme Hewitt, Feras E. Machour, Rhona Millar, Marek Adamowicz, Phil Ruis, Benura Azeroglu, Todd Fallesen, Harshil Patel, Steven Howell, Panagiotis Kotsantis, Michael Howell, Simon J. Boulton, Zornitsa Manova
| Nature Verified
Abstract Mutations in the ATRX chromatin remodeler confer a predisposition to a developmental genetic disorder and cancer, but how ATRX safeguards genome and telomere stability remains unresolved. Here, we uncover critical dependencies for the CTC1–STN1–TEN1 (CST) complex and RAD9A–HUS1–RAD1 (9-1-1) clamp in ATRX-deficient cells. ATRX–CST synthetic lethality manifests following accumulation of telomeric G-rich single-stranded DNA (ssDNA), which results in telomere loss and cell death.
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