Helen C. Barron

Abstract Histamine was the first canonical monoamine identified in the mammalian brain, yet arguably remains the least understood in its mechanistic contributions to human behaviour. Using a first-in-class causal probe (H3R inverse agonist pitolisant), we show how elevating histamine shapes offline and online temporal–hippocampal dynamics — sustaining episodic learning-related activity and polarising retrieval computations.

Keywords memory population spiking network oscillations hippocampus medial temporal lobe human brain ripples single neurons theta intracranial EEG Introduction Memory unfolds across an extended processing arc that spans experience and time, from learning through consolidation to recall.1,2,3 At the core of the brain-memory circuitry is the hippocampus, whose neurons support the representation of relationships between stimuli and events.4,5,6,7,8 During learning, hippocampal activity gives...

Abstract The mammalian brain organises knowledge about entities in the world and relationships between them using cognitive maps. When forming a cognitive map, there is a necessary trade-off between extending the map to make novel inferences, and storing a veridical copy of past experience. However, the neural mechanisms that control this trade-off remain unknown.