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Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
Keywords 5xFAD Alzheimer’s disease amyloid-β light-sheet microscopy amyloid plaque transgenic mouse Thy1 promoter Introduction Published almost 20 years ago, the 5xFAD mouse model serves as a robust and widely used tool to study amyloidosis in Alzheimer’s disease (AD) in vivo.
Dopamine in the songbird auditory cortex shapes auditory preference
Highlights • Zebra finch females vary in their song preferences • Song preferences are plastic and can be modified by infusions into auditory cortex • Dopamine receptor agonists altered preferences for less-preferred songs • Multiple mid- and hindbrain catecholaminergic regions project to the auditory cortex Summary Vocal communication signals can provide listeners with information about the signaler and elicit motivated responses.
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