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Helena L Crowell

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts

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By Helena L Crowell, Laura Llaó-Cid, Gerard Frigola, Samuel Gunz
| Wiley Online Library Verified
(CCC) cell–cell communication (CSR) class switch recombination (D/LZ) dark/light zone (FOV) field of view (GC) germinal center (SLO) secondary lymphoid organ (scRNA-seq) single-cell RNA sequencing (SMI) spatial molecular imaging (TBM) tingible body macrophages 1 Introduction Multicellular systems orchestrate function through an interplay of their molecular components and structural organization (e.g., tissue composition and architecture).
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Disentangling cell type and state transcriptional programs

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By Jiayi Wang, Helena L Crowell, Mark Robinson
| BioRxiv
Abstract Single-cell omics approaches profile molecular constituents of individual cells. Replicated multi-condition experiments in particular aim at studying how the molecular makeup and composition of cell subpopulations changes at the sample-level.
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The tidyomics ecosystem: enhancing omic data analyses - Nature Methods

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By William Hutchison, Timothy J. Keyes, Helena L Crowell, Eric Davis, Noriaki Sato, Lambda Moses, Boyd Tarlinton, Abdullah A. Nahid, Quentin Clayssen, Wancen Mu, Ji-Eun Park, Izabela Mamede, Min Hyung Ryu, Paulina Paiz, Chi-Lam Poon, Ming Lee Tang, Raphael Gottardo, Martin Morgan, Stuart Lee, Stephanie Hicks, Garry P. Nolan, Kara L. Davis, Anthony T. Papenfuss, Michael Love
| Nature Verified
Abstract The growth of omic data presents evolving challenges in data manipulation, analysis and integration. Addressing these challenges, Bioconductor provides an extensive community-driven biological data analysis platform. Meanwhile, tidy R programming offers a revolutionary data organization and manipulation standard. Here we present the tidyomics software ecosystem, bridging Bioconductor to the tidy R paradigm.
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