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Helene Bæk Juel on Muck Rack

Helene Bæk Juel

As seen in: Nature, Wiley Online Library, MDPI, EBioMedicine, Clinical Gastroenterology and Hepatology
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Articles

Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity - Nature Communications

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By Sara Stinson Verified, Yun Huang, Roman Thielemann, Evelina Stankevic, Helene Bæk Juel, Maja Thiele, Aleksander Krag, Oluf Borbye Pedersen, Jens-Christian Holm, Cilius Esmann Fonvig
| Nature Verified
Abstract Pediatric obesity is linked to multi-organ inflammation and an increased risk of cardiometabolic and steatotic liver disease. To identify circulating biomarkers of cardiometabolic risk, we performed proximity extension assay proteomics, to quantify 149 inflammation- and cardiovascular-related proteins in a cross-sectional study of 4024 children and adolescents (2377 with obesity and 1647 with normal weight).
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Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescents

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By Sara Stinson Verified, Roman Thielemann, Helene Bæk Juel, Peter Rossing
| EBioMedicine Verified
Keywords Lipidomics Genome-wide association study Children Cardiometabolic risk Mendelian randomisation Evidence before this study High-throughput lipidomics has enabled detailed mapping of individual molecular lipid species, offering a comprehensive snapshot of lipid metabolism. Observational studies have identified several lipid species as biomarkers for cardiovascular disease and type 2 diabetes in adults.
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Human antibody signatures towards the Chlamydia trachomatis major outer membrane protein after natural infection and vaccination

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By Byrne G.I, Statens Serum Institut, Sara Knudsen, Helene Bæk Juel
| EBioMedicine Verified
Summary Chlamydia trachomatis (CT) Major Outer Membrane Protein (MOMP) holds a neutralising epitope in the Variable Domain 4 (VD4), and this region’s immune dominance during infection is well known. This study aimed to assess the antibody response induced after infection and compare it for specificity and functionality to the response following vaccination with the vaccine CTH522, which contains VD4’s from serovars D, E, F, and G.
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