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Oluf Borbye Pedersen on Muck Rack

Oluf Borbye Pedersen

As seen in: Nature, Genome Medicine, Cell Reports Medicine, The Journal of Allergy & Clinical Immunology, iForm.se, kuntoplus.fi
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Articles

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases - Nature Communications

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By Kanta Chechi, Rima Chakaroun, Antonis Myridakis, Sofia K. Forslund-Startceva, Sebastién Fromentin, Trine Nielsen, Eugeni Belda, Edi Prifti, Pierre Bel Lassen, Gwen Falony, Sara Vieira-Silva, Julien Chilloux, Kazuhiro Sonomura, Lesley Hoyles, Laura Martinez-Gili, Francesco Pallotti, Petros Andrikopoulos, Francesc Puig-Castellví, Ines Y. Castro-Dionicio, Hugo Roume, Nicolas Pons, Emmanuelle Le Chatelier, Benoit Quinquis, Magali Berland, Michael T. Olanipekun, Matthias Blüher, Luis Pedro Coelho, Kevin Da Silva, Pilar Galan, Boyang Ji, Ana Neves, Christine Rouault, Joe-Elie Salem, Valentina Tremaroli, Tue H. Hansen, Nadja B. Søndertoft, Helle Pedersen, Peter Mark, Jens P Goetze, Lars Køber, Henrik Vestergaard, Torben Frøstrup Hansen, Jean-Daniel Zucker, Serge Hercberg, Fredrik Bäckhed, Ivica Letunic, Jean-Michel Oppert, Jens Christian Nielsen, Jeroen Raes, Ioanna Tzoulaki, Abbas Dehghan, Verena Zuber, Emmanuelle Bouzigon, Mark Lathrop, Parminder Raina, Philippe Froguel, Fumihiko Matsuda, Florence Demenais, Dominique Gauguier, Michael Stumvoll, Peer Bork, Oluf Borbye Pedersen, S. Ehrlich, Karine Clément, Marc-Emmanuel Dumas, Judith Aron-Wisneswky, Romina Pacheco Tapia, Nathalie Galleron, Manyi Jia, Angelos Manolias, Bridget Holmes, Solia Adriouch, Christian Lewinter, Taka-Aki Sato
| Nature Verified
Abstract Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function.
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pH regulates gut bacterial tryptophan metabolism - npj Biofilms and Microbiomes

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By Julius E. Brinck, Martin F. Laursen, Mikael Pedersen, Matthew Carey Verified, Nicola Procházková, Malte S. Jørgensen, Martin S. Mortensen, Lotte Lauritzen, Oluf Borbye Pedersen, Henrik M. Roager, Tine R. Licht, Anurag K. Sinha
| Nature Verified
Abstract Intestinal pH influences microbiota composition and activity, yet its impact on microbial metabolite production remains elusive. Gut bacterial tryptophan catabolism yields metabolites with opposing health effects. Indole, a precursor of indoxyl sulfate (IS), is linked to chronic kidney disease (CKD), while indolelactic acid (ILA) and indolepropionic acid (IPA) have positive health effects.
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Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity - Nature Communications

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By Sara Stinson Verified, Yun Huang, Roman Thielemann, Evelina Stankevic, Helene Bæk Juel, Maja Thiele, Aleksander Krag, Oluf Borbye Pedersen, Jens-Christian Holm, Cilius Esmann Fonvig
| Nature Verified
Abstract Pediatric obesity is linked to multi-organ inflammation and an increased risk of cardiometabolic and steatotic liver disease. To identify circulating biomarkers of cardiometabolic risk, we performed proximity extension assay proteomics, to quantify 149 inflammation- and cardiovascular-related proteins in a cross-sectional study of 4024 children and adolescents (2377 with obesity and 1647 with normal weight).
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