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Piwi maintains homeostasis in the Drosophila adult intestine
Introduction The epithelium is maintained by epithelial stem cells that undergo constant self-renewing divisions to replenish various types of damaged and lost epithelial cells. Epithelial stem cell function is regulated by both intrinsic and extrinsic mechanisms. The Drosophila midgut provides a genetically amenable model for studying these mechanisms ( ). The Drosophila midgut is composed of a monolayer of epithelial cells that rest on a thin layer of muscle cells.
Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis
Technical advances have given rise to a different way of looking at the evolution of cells: perhaps cell types are evolutionary units in their own right, with their own phylogeny.
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