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Hongying Shen on Muck Rack

Hongying Shen

As seen in: Nature, MDPI, BioRxiv, Cell Press, The Hechinger Report
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Articles

Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo

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By Meilin Fernandez Garcia, Kayla G Retallick-Townsley, April Pruitt, Elizabeth Davidson, Novin Balafkan, Jonathan Warrell, Zhiyuan Chu, Yi Dai, Sarah Fitzpatrick Verified, Ran Meng, Annabel Sen, Sophie Cohen, Suha Khan, Charlotte Becker, Jenny Liu, Susanna Liu, Sadaf Ghorbani, Marisa DeCiucis, Prashant Emani, Huanyao Gao, Hongying Shen, Mark Gerstein, Zuoheng Wang, Laura M Huckins, Ellen Hoffman, Kristen J. Brennand, Tzu-Chieh Huang, Alfred Kibowen, Olivia Livoti, Grace Dossou, Jen Cheung, P. J. Michael Deans
| Nature Verified
Abstract Diverse risk genes have been identified for neurodevelopmental disorders (NDDs), but how these genes converge on similar biological pathways in neurons, and thus give rise to similar phenotypes, is unclear.
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JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux

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By Layla M. Nassar, Xiaojian Shi, Agnes Roczniak-Ferguson, Hongying Shen
| BioRxiv
Abstract Lysosomes break down macromolecules, clear cellular waste and recycle nutrients such as cystine. We describe a novel mechanism whereby JIP4 regulates lysosomal cystine storage by controlling the abundance of cystinosin (CTNS), the transporter responsible for lysosomal cystine efflux. To this end, JIP4, previously characterized as a motor adaptor and kinase signaling scaffold, suppresses TMEM55B-dependent ubiquitylation of CTNS.
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Study on Labor Productivity Improvement Based on Situational Awareness and Improved Value Stream Mapping

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By Lixuan Jiang, Hongying Shen, Jinhua Zhang
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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