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Hoyin Chu on Muck Rack

Hoyin Chu

As seen in: Nature, Science Magazine
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Articles

Sequence and structural determinants of efficacious de novo chimaeric antigen receptors

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By Hoyin Chu, Ruofan Li, Benan Nalbant, Laura C. Kida, Zeyu Tang, Joseph R Palmeri, Caleb A Lareau, Arthur Chow, Abdul Vehab Dozic
| Nature Verified
Abstract Advances in generative protein design using artificial intelligence (AI) have enabled the rapid development of binders against heterogeneous targets, including tumour-associated antigens. Despite extensive biochemical characterization, these novel protein binders have had limited evaluation in candidate therapeutics, including chimaeric antigen receptor (CAR) T cells.
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Genomic correlates of clinical CAR T cell activity

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By WeiWei Yu, Mark Leick, Maria Pia Holgado, Baihe Sun, Filippo Birocchi, Kathleen Gallagher Verified, Seunghun Han, Grace Martin, Harrison Silva, Rebecca Larson, Tyler M. Chinsky, Hoyin Chu, Christopher Reilly, Michael Kann, Bryan D. Choi, Sabrina Y. Camp, Riaz Gillani, Merle K. Phillips, Tamina Kienka, Stefanie R Bailey, Charlotte Graham, Max Jan, Nicholas Moore, Nora K. Horick, Alexandra Bratt
| Science Magazine Verified
Editor’s summary Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Editor’s summary Chimeric antigen receptor T cell (CAR T cell) therapies are generated from human T cells and carry germline variants that may affect their function. Leick et al.
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Patient-partnered multiomics reveals the molecular architecture of angiosarcoma

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By Hoyin Chu, Brittany A Borden, Christopher Reilly, Beena S. Thomas, Erica Pimenta, Seunghun Han, Sabrina Y. Camp, Riaz Gillani, Jacob Gutierrez, Caleb A Lareau, Matthew Nagy, Jeremy Johnson, Lauren Sterlin, Delia Sosa, Ilan Small, Mary McGillicuddy, Nouf Abdullah Alharbi, Jason L. Hornick, Hani Choudhry, Diane Diehl, Eliezer Van Allen, Nikhil Wagle, Corrie A. Painter, Saud H. AlDubayan, Marissa Hollyer, Kolbe Phelps, Oyin Alao, Hadley Grundman, Will Terzi, Elana Anastasio, Parker Chastain, Priyanka Bhakhri
| Nature Verified
Abstract Angiosarcoma is a poorly understood sarcoma due to its high heterogeneity and rarity. Here we show a comprehensive clinical and molecular analysis of a large cohort of 254 angiosarcoma patients through the patient-partnered Angiosarcoma Project. By integrating transcriptomic, somatic, and germline variant data, we find that subcutaneous angiosarcomas frequently exhibit TGF-β and receptor tyrosine kinase signaling upregulation, with driver mutations in KDR, PLCG1, and POT1.
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