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Oyin Alao on Muck Rack

Oyin Alao

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Articles

Patient-partnered multiomics reveals the molecular architecture of angiosarcoma

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By Hoyin Chu, Brittany A Borden, Christopher Reilly, Beena S. Thomas, Erica Pimenta, Seunghun Han, Sabrina Y. Camp, Riaz Gillani, Jacob Gutierrez, Caleb A Lareau, Matthew Nagy, Jeremy Johnson, Lauren Sterlin, Delia Sosa, Ilan Small, Mary McGillicuddy, Nouf Abdullah Alharbi, Jason L. Hornick, Hani Choudhry, Diane Diehl, Eliezer Van Allen, Nikhil Wagle, Corrie A. Painter, Saud H. AlDubayan, Marissa Hollyer, Kolbe Phelps, Oyin Alao, Hadley Grundman, Will Terzi, Elana Anastasio, Parker Chastain, Priyanka Bhakhri
| Nature Verified
Abstract Angiosarcoma is a poorly understood sarcoma due to its high heterogeneity and rarity. Here we show a comprehensive clinical and molecular analysis of a large cohort of 254 angiosarcoma patients through the patient-partnered Angiosarcoma Project. By integrating transcriptomic, somatic, and germline variant data, we find that subcutaneous angiosarcomas frequently exhibit TGF-β and receptor tyrosine kinase signaling upregulation, with driver mutations in KDR, PLCG1, and POT1.
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