Hyeji Jun

Cancer Cell Available online 22 January 2026 IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma Author links open overlay panelTriantafyllia Karakousi 1, Vanessa Cristaldi 1, Maria Luiza Lopes de Oliveira 1, Ines Delclaux 1, Naomi R. Besson 1, Luiz Henrique Geraldo 1 2, Tania J. González-Robles 3 4 5, Devyon R. McDonnough 1, Daniel Martinez-Krams 1 6, Gabrielle da Silva 1, Alec P.

Results Given the critical role of prompt optimization in enhancing LLM performance, we first evaluated whether designing a specific prompt structure would optimize the accuracy of a representative LLM (Mistral Nemo 12B) in accurately retrieving FDA-approved biomarker-based (“precision”) oncology therapies.25 We tested four distinct prompt strategies (see STAR MethodsTable 1). All evaluated queries were formulated using the structured data from MOAlmanac v2024-04-11 (Tables S1 and S2).

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