Hyunu R. Kim

Keywords epigenetics lymphocytes inflammation infection differentiation cell fate cytokines AP-1 factors STAT factors Get full text access Log in, subscribe or purchase for full access. References 1. Chung, H.K. ∙ McDonald, B. ∙ Kaech, S.M. The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates J. Exp. Med. 2021; 218, e20201730 2. Adams, N.M. ∙ Grassmann, S. ∙ Sun, J.C. Clonal expansion of innate and adaptive lymphocytes Nat. Rev.

Abstract Natural killer (NK) cells are innate lymphocytes that play a critical role in host defense against viral infection. In addition to rapid effector cytokine production and direct cytotoxicity, NK cells exhibit features of adaptive immunity, including the capacity to undergo robust antigen-specific clonal proliferation and to generate immunological memory1,2,3.

Abstract Natural Killer (NK) cells are innate cytotoxic lymphocytes that possess features of adaptive immunity, including antigen specificity and clonal expansion. NK cells rapidly respond to cytokines released during the innate phase of viral infection and are thought to migrate from circulation into infected organs to execute their early effector functions. However, recent evidence suggests that tissue-resident NK cells are among the first responders to viral infection.