Endi K. Santosa

Abstract Fibroblast–macrophage crosstalk is well-established in vitro, and fibroblast-derived colony-stimulating factor 1 (CSF1) supports macrophages in select tissues. However, whether macrophages regulate fibroblasts in vivo remains unknown. Leveraging genetic mouse models, single-cell multi-omics, flow cytometry and imaging, we show that fibroblast depletion or loss of fibroblast-derived growth factors impacts skin macrophage populations in the dermis and hypodermis.

Keywords epigenetics lymphocytes inflammation infection differentiation cell fate cytokines AP-1 factors STAT factors Get full text access Log in, subscribe or purchase for full access. References 1. Chung, H.K. ∙ McDonald, B. ∙ Kaech, S.M. The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates J. Exp. Med. 2021; 218, e20201730 2. Adams, N.M. ∙ Grassmann, S. ∙ Sun, J.C. Clonal expansion of innate and adaptive lymphocytes Nat. Rev.

Abstract Natural killer (NK) cells are innate lymphocytes that play a critical role in host defense against viral infection. In addition to rapid effector cytokine production and direct cytotoxicity, NK cells exhibit features of adaptive immunity, including the capacity to undergo robust antigen-specific clonal proliferation and to generate immunological memory1,2,3.