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Ibithal Benhsaien on Muck Rack

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Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria

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By Rui Yang, Federico Mele, Lisa Worley, David Langlais, Jérémie Rosain, Carys A. Croft, Peng Zhang, David Jarrossay, Daniela Latorre, Jing Han, Masato Ogishi, Conor Gruber, Ibithal Benhsaien, Houda Elarabi, Jean-Marc Doisne, Marc Weisshaar, Yichao Shen
| ScienceDirect Verified
Highlights • Human inherited T-bet deficiency underlies severe mycobacterial disease • The development of a variety of IFN-γ-producing lymphocyte subsets is impaired • The production of IFN-γ by innate and innate-like lymphocytes is impaired • Mycobacterium-specific αβ CD4 TH1∗ and CD8 cells produce IFN-γ normally Summary Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease.
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