Irene Adán-Barrientos

Mice Male and female C57BL/6 CD45.2 WT, CD45.1 WT, Oma1-/-, and Isg15-/- mice maintained on chow diet were used between 8 and 12 weeks of age for all experiments. The local ethics committee approved all animal studies (PROEX 026/17 and PROEX 115/19), and all animal procedures were compliant with the EU Directive 2010/63/EU and Recommendation 2007/526/EC regarding the protection of animals used for experimental and other scientific purposes, enforced by the Spanish law under RD 1201/2005.

APC antigen presenting cell cDC conventional dendritic cell GC germinal center MHCII major histocompatibility complex II NP nitro-phenyl hapten OVA ovalbumin PBS phosphate buffered saline pDC plasmacytoid dendritic cell TCR T cell receptor Tfh T follicular helper cell Tfr T follicular regulatory cell Th1 type 1 helper T cell Treg regulatory T cell 1 INTRODUCTION An effective immune response against infectious agents is characterized by the efficient induction of antigen-specific lymphocyte...

1 Introduction Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has given rise to one of the worst pandemics in recent history. As July 2023, the virus has infected more than 767 million individuals, causing over 6.9 million deaths (https://covid19.who.int/).