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Ivan Imaz-Rosshandler on Muck Rack

Ivan Imaz-Rosshandler

As seen in: Genome Biology, Cell Press, Cell Stem Cell
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Articles by Ivan Imaz-Rosshandler

Mesenchymal drift: A convergent framework for the hallmarks of aging

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By Jinlong Y. Lu, William B. Tu, Shuai Ma, Zaijun Ma, Ivan Imaz-Rosshandler, Mingxi Weng, Jing Qu, Concepcion Rodriguez Esteban, Pradeep Reddy, Guang-Hui Liu
| Cell Press Verified
Keywords aging epithelial-to-mesenchymal transition endothelial-to-mesenchymal transition rejuvenation biomarkers partial reprogramming Yamanaka factors fibrosis cellular identity and plasticity geroscience Introduction Aging biology is commonly framed through a set of canonical “hallmarks.” Since their original formulation,1 these hallmarks have expanded from nine to twelve2 and more recently to fourteen,3 reflecting both the growing complexity of aging biology and the field’s effort to...
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Tissue morphology influences the temporal program of human brain organoid development

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By Ivan Imaz-Rosshandler, Jérôme Boulanger, Laura Pellegrini, Madeline A. Lancaster
| Cell Stem Cell Verified
Highlights • Neural organoid protocol variations influence morphology and tissue architecture • Advanced morphology correlates with greater transcriptomic similarity to in vivo • Proper cellular position correlates with accurate fate progression • Perturbing morphology and cytoarchitecture disrupts temporal identity Summary Progression through fate decisions determines cellular composition and tissue architecture, but how that same architecture may impact cell fate is less clear.
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Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation

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By Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar
| Genome Biology Verified
Melania Barile1,2, 1,2, Isabella Inzani3, Shila Ghazanfar4, Jennifer Nichols2,5, John C. Marioni4,6,7, Carolina Guibentif1,2,8 & Berthold Göttgens ORCID: orcid.org/0000-0001-6302-57051,2 Genome Biology volume 22, Article number: 197 (2021) Cite this article Abstract Background Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states.
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Diverse Routes toward Early Somites in the Mouse Embryo

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By Carolina Guibentif, Jonathan Griffiths, Shila Ghazanfar, Ivan Imaz-Rosshandler
| Cell Press Verified
Highlights • Multiple transcriptional trajectories underlie somite emergence • Outlining the in vivo molecular journey toward the anterior T-independent somites • T does not negatively regulate Sox2 to control neural output at E8.5 Summary Somite formation is foundational to creating the vertebrate segmental body plan. Here, we describe three transcriptional trajectories toward somite formation in the early mouse embryo.
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