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Articles by Ivan Soltesz
Developmental xenocortication using human-derived organoids in mice
Abstract The inaccessibility of human brain tissue limits the study of human development and function, a challenge that human stem-cell-derived neural models are beginning to address1,2. Transplantation of neural organoids into rodent hosts enables the in vivo study of aspects of human neurodevelopment and circuit function, alongside behavioural phenotyping of the host animals.
Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo
Abstract The light chain of tetanus neurotoxin (TeNT) is a metalloprotease that potently inhibits synaptic transmission by cleaving the endogenous vesicle fusion protein VAMP2, but its constitutive activity prevents spatiotemporal precision. To address this, we engineered light-activated TeNT (LATeNT) by inserting the light-sensitive LOV domain into an allosteric site and optimizing dynamic range via directed evolution.
Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice
Keywords dentate gyrus interneuron parvalbumin somatostatin hippocampus optogenetics dentate spikes theta sleep Get full text access Log in, subscribe or purchase for full access. References 1. Tingley, D. ∙ Buzsáki, G. Routing of Hippocampal Ripples to Subcortical Structures via the Lateral Septum Neuron. 2020; 105:138-149.e5 2. Nokia, M.S. ∙ Gureviciene, I. ∙ Waselius, T. ... Hippocampal electrical stimulation disrupts associative learning when targeted at dentate spikes J. Physiol.
Noncanonical circuits, states, and computations of the hippocampus
Editor’s summary The hippocampus is one of the most studied brain areas because of its major role in fundamental brain functions including learning, memory, and spatial navigation. In a Review, Farrell and Soltesz focused on the role of overlooked areas and circuits within the hippocampus, the CA2 region, the indusium griseum, and the fasciola cinereum.
Integrating endocannabinoid signaling, CCK interneurons, and hippocampal circuit dynamics in behaving animals
Keywords endocannabinoid CB1 receptor behavior hippocampus cholecystokinin interneuron inhibition translational disease brain state Introduction The brain by dry weight is composed mostly of lipids, and endocannabinoids (eCBs) form a major class of lipid-derived information-carrying molecules. eCBs have important roles in a wide range of neuronal phenomena, including appetite regulation, temperature regulation, pain perception, brain development, learning and memory, and motor functions.
"Neural and Behavioural State Switching During Hippocampal Dentate Spik" by Jordan S Farrell, Ernie Hwaun et al.
Keywords Animals, Mice, Hippocampus, Memory Consolidation, Arousal, Action Potentials, Neural Inhibition, Cognition, Brain Waves, Male, Female Abstract Distinct brain and behavioural states are associated with organized neural population dynamics that are thought to serve specific cognitive functions1–3.
Author Correction: Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature
Correction to: Nature https://doi.org/10.1038/s41586-024-08282-3 Published online 4 December 2024 In the version of the article initially published, the middle initial of Alice Y. Ting was missing, and the Acknowledgements omitted thanks to Sean A. Yamada-Hunter, Louai Labanieh and Crystal L. Mackall for helpful discussions and protocols related to T cells. The corrections have been made in the HTML and PDF versions of the article.
Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature
Abstract Synthetic receptors that mediate antigen-dependent cell responses are transforming therapeutics, drug discovery and basic research1,2. However, established technologies such as chimeric antigen receptors3 can only detect immobilized antigens, have limited output scope and lack built-in drug control3,4,5,6,7.
Inhibitory plasticity supports replay generalization in the hippocampus - Nature Neuroscience
Abstract Memory consolidation assimilates recent experiences into long-term memory. This process requires the replay of learned sequences, although the content of these sequences remains controversial. Recent work has shown that the statistics of replay deviate from those of experience: stimuli that are experientially salient may be either recruited or suppressed from sharp-wave ripples.
A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations - Nature Communications
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In experimental animals, SPW-Rs can be confidently measured with linear electrode arrays, as the sharp wave and ripple components are simultaneously recorded across CA1 layers (str. oriens, pyramidal layer and str. radiatum). The current source-density (CSD) profiles of both events can be identified by automated detection thresholds, then visually inspected by expert operators5.
By Simon Henin, Elizabeth A. Buffalo, Jordan S. Farrell, David Foster, Loren M. Frank, Kari L. Hoffman, Joshua Jacobs, Lin Li, Attila Losonczy, Rafael Malach, Bruce L. McNaughton, Yitzhak Norman, Andrea Navas-Olive, Jon W. Rueckemann, Ivan Soltesz, Bernhard P. Staresina, Kareem A. Zaghloul, Michaël Zugaro, Saman Abbaspoor, Jennifer A. Guidera, Zhenrui Liao, John J. Sakon
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Nature
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Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics
Discussion In this study we used a simple recurrent spiking network model of hippocampal area CA3 to investigate the structural and functional requirements for offline replay of spatial memories. We optimized synaptic, cellular and network parameters of the network to produce population dynamics that match experimentally observed sparsity, selectivity and rhythmicity.
From single‐neuron dynamics to higher‐order circuit motifs in control and pathological brain networks
Topical Review Handling Editors: Katalin Toth & Michael Okun Abstract The convergence of advanced single-cell in vivo functional imaging techniques, computational modelling tools and graph-based network analytics has heralded new opportunities to study single-cell dynamics across large-scale networks, providing novel insights into principles of brain communication and pointing towards potential new strategies for treating neurological disorders.
Transcriptional readout of neuronal activity via an engineered Ca2+-activated protease
Significance Molecular reporters that “remember” the activity history of a cell and give a corresponding signal that can be read out by imaging, sequencing, or other modalities are valuable tools for the study of neural networks. Here, we develop a reporter that drives stable expression of any transgene (such as a fluorescent protein) in response to cellular calcium activity during a user-defined time window.
Deep brain optogenetics without intracranial surgery
Abstract Achieving temporally precise, noninvasive control over specific neural cell types in the deep brain would advance the study of nervous system function. Here we use the potent channelrhodopsin ChRmine to achieve transcranial photoactivation of defined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7 mm with millisecond precision.
Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks
Current drug treatments for epilepsy attempt to broadly restrict excitability to mask a symptom, seizures, with little regard for the heterogeneous mechanisms that underlie disease manifestation across individuals. Here, we discuss the need for a more complete view of epilepsy, outlining how key features at the cellular and microcircuit level can significantly impact disease mechanisms that are not captured by the most common methodology to study epilepsy, electroencephalography (EEG).
CA1 pyramidal cell diversity enabling parallel information processing in the hippocampus
Lee, S. H. et al. Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron 82, 1129–1144 (2014). In this study, the authors provide evidence for biased excitatory–inhibitory microcircuits in the mouse hippocampus. Deep CA1 pyramidal cells were found to receive stronger inhibition from parvalbumin-expressing basket cells, while superficial pyramidal cells were found to provide stronger excitatory inputs to basket cells.
Hippocampal Dentate Mossy Cells Improve Their CV and Trk into the Limelight
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. PreviewHippocampal Dentate Mossy Cells Improve Their CV and Trk into the Limelight© 2017 Elsevier Inc.
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