Jacqueline K. Barton

Over the past 25 years, collective evidence has demonstrated that the DNA base-pair stack serves as a medium for charge transport chemistry in solution and on DNA-modified gold surfaces. Since this charge transport depends sensitively upon the integrity of the DNA base pair stack, perturbations in base stacking, as may occur with DNA base mismatches, lesions, and protein binding, interrupt DNA charge transport (DNA CT).

Highlights • PYO and PCN bind extracellular DNA, which facilitates their retention in biofilms • Electrode biofilms support fast PYO electron transfer and slow PYO loss • Phenazines rapidly exchange electrons and are capable of DNA charge transfer in vitro Summary Redox cycling of extracellular electron shuttles can enable the metabolic activity of subpopulations within multicellular bacterial biofilms that lack direct access to electron acceptors or donors.

In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model Stephanie D. Threatt, Timothy W. Synold, Jun Wu, Jacqueline K. Barton Proceedings of the National Academy of Sciences Jul 2020, 202006569; DOI: 10.1073/pnas.2006569117