James N. Sleigh on Muck Rack

James N. Sleigh

Verified
London
As seen in: Journal of Anatomy, Nature, Wiley Online Library, Biomed Central (BMC), Cell Press, The Lancet, The Journal of Clinical Investigation
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Articles

Refining gene delivery to skeletal muscle with a dual-strategy approach of muscle-tropic AAV capsids and muscle-specific promoters.

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By Annalucia L. Darbey, Wenanlan Jin, Linda Greensmith, James N. Sleigh Verified
| biorxiv.org
Abstract Viral vector technologies based on adeno-associated virus (AAV) have demonstrated promising ability to deliver genetic cargo to a range of organs in vivo, with several novel candidates showing clinical efficacy in human trials over the past decade. However, naturally occurring AAV serotypes are limited in their ability to target skeletal muscle, an important gene therapy target for many neuromuscular disorders.
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Age‐specific and compartment‐dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

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By James N. Sleigh Verified, Francesca Mattedi, Sandy Richter
| Wiley Online Library Verified
BCECF 2′,7′-bis-(2-carboxyethyl)-carboxyfluorescein DIV days in vitro DRG dorsal root ganglion FLIM fluorescence lifetime imaging microscopy GEMs genetically-encoded multimeric nanoparticles MFCs microfluidic chambers NA numerical aperture siRNA small interfering RNA TR-FAIM time-resolved fluorescence anisotropy imaging 1 INTRODUCTION Ensuring precise distribution and functionality of mitochondria is essential for maintaining cellular homeostasis.
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The node of Ranvier influences the in vivo axonal transport of mitochondria and signalling endosomes

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By Federico Abatecola, James N. Sleigh Verified, Andrew Paul Tosolini, Samuele Negro
| biorxiv.org
Abstract Efficient long-range axonal transport is essential for maintaining neuronal function, and perturbations in this process underlie severe neurological diseases. We have previously demonstrated that signalling endosomes are transported in vivo at comparable speeds across motor neurons (MNs) innervating different hindlimb muscles, as well as between forelimb and hindlimb peripheral nerves. In contrast, axonal transport is faster in MNs compared to sensory neurons innervating the same muscle.
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