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Janet Iwasa on Muck Rack

Janet Iwasa

Salt Lake City, Utah
As seen in: Nature, Wiley Online Library, PLOS Biology, TED, EurekAlert!, Science Magazine, Cell Press
Head of the Animation Lab & writer of the RCSB PDB Molecule of the Month
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Articles

ESCRT-III assembles around mis-segregated DNA to protect genome stability

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By James Glover, Nathaniel Talledge, John McCullough, Akram Alian, Sahil Kamboj, Henry Nguyen, Matthew Lalonde, Elliott L. Paine, Barbie K. Ganser-Pornillos, Leandro N. Ventimiglia, Dollie LaJoie, Janet Iwasa, Christopher P. Arthur, D. John Lee, Meera Venkatesh, Lydia Arnold, Jarrod S Johnson, Adam Frost, Wesley I. Sundquist, Juan Martin-Serrano, Jessica B. A. Sadler, Nathaniel W. M. Dempsey, Dawn M. Wenzel, Frank R. Moss III, Katharine S. Ullman
| Nature Verified
Abstract Chromosome mis-segregation events that remain unresolved during cytokinesis threaten genome stability. Persistent ultrafine DNA bridges engage the Aurora B-dependent abscission checkpoint (termed NoCut), which delays abscission by phosphorylating components of the ESCRT complex. Here we show that NoCut surveillance repurposes human ESCRT-III, the membrane-remodeling complex that seals the reforming nuclear envelope in anaphase.
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Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks - Nature Communications

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By Matthew A Schaich, Janet Iwasa, Bret D. Freudenthal
| Nature Verified
Abstract Poly(ADP-ribose) polymerase 1 (PARP1) detects DNA strand breaks that occur in duplex DNA and chromatin. Here, correlative optical tweezers and fluorescence microscopy reveal how single molecules of PARP1 identify single-strand breaks (i.e., nicks), undamaged nucleosome core particles (NCP) and NCPs containing DNA nicks. Fluorescently-tagged PARP1 or PARP2 from nuclear extracts binds nicks with nanomolar affinity but does not engage undamaged dsDNA regions.
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Mechanisms for licensing origins of DNA replication in eukaryotic cells - Nature Structural & Molecular Biology

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By Bruce Stillman, Janet Iwasa
| Nature Verified
Abstract The initiation of DNA replication in eukaryotic cells begins with the assembly of pre-replicative complexes (pre-RCs) at many sites along each chromosome during the G1 phase of the cell cycle. Pre-RCs license each chromosome for duplication during S phase and mark the origins of DNA replication.
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