Jangsuk Oh on Muck Rack

Jangsuk Oh

As seen in: Cell Reports Medicine, eLife
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Articles

Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density

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By Alex Quan, Dan Li, Laura Hutchins, Constanza Rodriguez, Jangsuk Oh, Hsi-En Tsao, Madeline R. Spetz, Elijah F. Edmondson, Dana Ashworth, Rui Zheng, Jing Zhou, Jinyun Chen, Hongbing Zhang, Cheng Liu, Rosa Nguyen, Nan Li, Mitchell Wong Ho, Mingyu Huo, Jingbao Liu, Guangyan Xiong
| Cell Reports Medicine Verified
Keywords neuroblastoma glypican-2 GPC2 monoclonal antibody antibody humanization gamma/delta TCR antibody-TCR AbTCR chimeric antigen receptor CAR cell therapy CD30 Introduction Neuroblastoma is the second most frequently occurring extracranial solid tumor in children, accounting for 8%–10% of all pediatric cancers and 15% of cancer-related deaths in children.1 A major challenge in treating many cancers, including neuroblastoma, is the lack of effective therapeutic targets.
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A new pipeline SPICE identifies novel JUN-IKZF1 composite elements

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By Peng Li, Sree H Pulugulla, Sonali Das, Jangsuk Oh
| eLife
eLife assessment This valuable study presents a screening pipeline (SPICE) for detecting DNA motif spacing preferences between TF partners. SPICE predicts previously known composite elements, but experiments to elucidate the nature of the predicted novel interaction between JUN and IKZF1 are incomplete. These experiments would benefit from more rigorous approaches using other databases to explore additional relevant data.
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A new pipeline SPICE identifies novel JUN-IKZF1 composite elements

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By Peng Li, Sree H Pulugulla, Sonali Das, Jangsuk Oh
| biorxiv.org
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