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Jez L. Marston

As seen in: Frontiers, BioRxiv, Cell Press, Mary Ann Liebert, Inc.
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Articles

Human endogenous retrovirus profiling reveals heterogenous expression in cutaneous melanoma

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By Tongyi Fei, Bhavya Singh, Nicholas Dopkins, Jez L. Marston, Jasmine H. Francis, Douglas F Nixon, Alexander N. Shoushtari, Matthew L. Bendall
| Frontiers
Abstract Background: Cutaneous melanoma (CM) is a cancer of the pigment-producing melanocytes of the skin. Advances in treatment with immune checkpoint inhibitors (ICI) have greatly improved the outcomes, although not all patients with CM respond to ICI. Emerging evidence shows that ICI responsiveness is correlated with the expression of certain human endogenous retroviruses (HERVs). We aimed to investigate the relationships between HERV expression and outcomes in patients with CM.
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A single-cell transposable element atlas of human cell identity

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By Helena Reyes-Gopar, Jez L. Marston, Bhavya Singh, Matthew Greenig
| BioRxiv
Abstract Single cell RNA sequencing (scRNA-seq) is revolutionizing the study of complex biological systems. However, most sequencing studies overlook the contribution of transposable element (TE) expression to the transcriptome. In both scRNA-seq and bulk tissue RNA sequencing (RNA-seq), quantification of TE expression is challenging due to repetitive sequence content and poorly characterized TE gene models.
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Locus specific human endogenous retroviruses reveal new lymphoma subtypes

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By Bhavya Singh, Nicholas Dopkins, Tongyi Fei, Jez L. Marston
| BioRxiv
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