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Articles by Ji Lu
HDAC4 modulates p27 Kip1 -mediated cell cycle progression in castration-resistant prostate cancer
Abstract Class IIa histone deacetylase 4 (HDAC4) primarily regulates transcription through scaffolding functions, despite its limited intrinsic deacetylase activity. Here, we identify a critical oncogenic role for HDAC4 in metastatic castration-resistant prostate cancer (mCRPC), where it is significantly overexpressed and drives disease progression by promoting proliferation, survival, and tumorigenesis.
A potassium-based single-atom catalyst enables acute lung injury immunotherapy in mice by inhibiting macrophage pyroptosis
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Abstract Acute lung injury (ALI), which can have a mortality rate approaching 40%, lacks effective therapies. Macrophage pyroptosis represents a pro-inflammatory event and a potential therapeutic target. Here, we report a single-atom immunomodulator, a potassium-based single-atom catalyst (K-SAC) with K–N4 sites, that suppresses macrophage pyroptosis for ALI therapy through antioxidant catalysis.
By Xiangyu Lu, Xuan Shi, Yanmin Jian, Cai Sun, Lijie Mao, Si Chen, Fang Huang, Ji Lu, Zhiyi Song, Xin Li Verified, Yongjun Chen, Ke Li, Xin Lv, Jianlin Shi, Yuanru Zhao, Guanning Liu
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Nature
Verified
Broadband Vibration Attenuation of the pipe structure under the Synergistic Effect of Acoustic Black Hole and Local Resonance
In recent years, acoustic black hole (ABH) has developed rapidly in vibration acoustics as a wave manipulation technology. It is currently being tried to be applied to the vibration control of industrial pipes. Usually, the ABH structure has an obvious vibration suppression ability in the middle and high frequency range, but the vibration suppression is insufficient in the low frequency range; at the same time, the embedded ABH structure leads to structural weakening.
Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond
Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond Cuproptosis, a novel form of copper (Cu)-dependent programmed cell death, is induced by directly binding Cu species to lipoylated components of the tricarboxylic acid (TCA) cycle. Since its discovery in 2022, cuproptosis has been closely linked to the field of materials science, offering a biological basis and bright prospects for the use of Cu-based nanomaterials in various disease treatments.
A Cross-Language Study of Tonal Variants in Mandarin in Different Attentional Conditions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Impact of Digital Audio Techniques and Software Technology on Students’ Engagement and Participation in Music Classes
Ayuda Buscar en la ayuda Buscar en la ayuda Impact of Digital Audio Techniques and Software Technology on Students’ Engagement and Participation in Music Classes Ji Lu [1] [1] Jimei University Localización: El profesional de la información, ISSN-e 1699-2407, ISSN 1386-6710, Vol.
Global Trends and Innovations in Forest Ecological Compensation: An Interdisciplinary Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Thieme E-Journals - Synlett
Buy Article Permissions and Reprints All articles of this category The environmentally benign synthesis of indoline boronic esters, especially through a way of arylboration to alkenes, remains a challenge due to the use of transition metals or high-temperature conditions. We described a photoinduced metal-free arylboration of unactivated alkenes for the synthesis of indoline boronic esters and 1,2,3,4-tetrahydroquinoline boronic ester in good yields.
An Earlier Spring Phenology Reduces Vegetation Growth Rate during the Green-Up Period in Temperate Forests
Open AccessArticle by 1, 2,*, 1,*, 1, 3, 4, 1 and 5 1 East China Survey and Planning Institute of National Forest and Grassland Administration, Hangzhou 310019, China 2 College of Water Sciences, Beijing Normal University, Beijing 100875, China 3 Key Laboratory of Forest Ecology and Environment of the National Forestry and Grassland Administration, Ecology and Nature Conservation Institute, Chinese Academy of Forestry, Beijing 100085, China 4 College of Grassland Agriculture, Northwest A&F...
TRAF6 promotes chemoresistance to paclitaxel of triple negative breast cancer via regulating PKM2‐mediated glycolysis
1 INTRODUCTION In breast cancer, which is the most frequent malignancy in women,1 triple-negative breast cancer (TNBC), detected as negative expression of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 receptor (HER2) by immunohistochemistry, is easy to relapse and metastasize.2 Given a lack of effective endocrinotherapy and molecular targeted therapy, the main treatment option is chemotherapy for TNBC.3, 4 However, TNBC patients usually develop...
Electrochemical detection of SARS-CoV-2 based on copper nanoflowers-triggered in situ growth of electroactive polymers
Electrochemical detection of SARS-CoV-2 based on copper nanoflowers-triggered in situ growth of electroactive polymers Ji Lu, Xiaotian Zhou, Yi Li, Min Yu, Siyuan Fu, Zhiling Qu, Yanling Li, Jinfeng Miao and Yuanyuan Xu Abstract SARS-CoV-2, the pathogen of COVID-19, has introduced massive confirmed cases and millions of deaths worldwide, which poses serious public health threat.
Novel Multiplexed Amplicon-Based Sequencing to Quantify SARS-CoV-2 RNA from Wastewater
The application of wastewater-based epidemiology (WBE) to support the global response to the COVID-19 pandemic has shown encouraging outcomes. The accurate, sensitive, and high-throughput detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in municipal wastewater is critical for WBE. Here, we present a novel approach based on multiplexed amplicon-based sequencing, namely the ATOPlex platform, for detecting SARS-CoV-2.
Disinfection spreads antimicrobial resistance
During the COVID-19 pandemic, the use of disinfectants, alcohol-based hand sanitizers, and antiseptic hand wash has surged. As a precaution, many authorities have also increased chlorine dosage in wastewater disinfection to achieve a free chlorine residual concentration greater than 6.5 mg/liter (1), despite evidence that a free chlorine residual of just above 0.5 mg/liter can completely inactivate human coronavirus (2).
Antiepileptic drug carbamazepine promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes within and across bacterial genera
Carbamazepine significantly increases the conjugative transfer frequency To test the effects of carbamazepine on conjugative transfer, we evaluated both the intragenera and intergenera transfer of the RP4 plasmid under the exposure of seven different sub-MIC concentrations of carbamazepine (in the range of 0.05–50 mg/L). These tests included the environmentally relevant concentrations of carbamazepine at between 0.05 and 0.5 mg/L.
Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy
Convergent total synthesis of bryostatin 8 has been accomplished via an organosilane-based strategy. The C ring is constructed stereoselectively through geminal bis(silane)-based [1,5]-Brook rearrangement, and the B ring through geminal bis(silane)-based Prins cyclization, efficiently joining the northern and southern parts of the molecule.
The effect of perceived carrier-ingredient fit on purchase intention of functional food moderated by nutrition knowledge and health claim
Abstract Purpose The purpose of this paper is to examine how the purchase intention of functional food is influenced by the perception of carrier-ingredient fit, that is, to what extent the carrier product and functional ingredient are intuitively perceived to be matched, and how such influence is moderated by consumers’ prior nutrition knowledge and provided health claim.
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