Ying Mao
As seen in:
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Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
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Abstract Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ~40-50% of cases1,2. However, current therapies fail to target most such mutations because the mutant proteins typically lack defined drug-binding pockets, and restoring the endogenous function has proven challenging.
By Jingkun Zeng, Zhiyuan Cheng, Huadong Chen, Zhaojun Wang, Jared Thompson, Kadin T. Crosby, Hesong Han, Arushi Singhal, Wayne Ngo, Chenglong Xia, Daniel Rosas-Rivera, Zeyuan Zhang, Ying Mao, Morgan E. Diolaiti, Giselle Lee, John F. X. Diffley, Yixuan Song, Longhui Qiu, Nathan M. Krah, Niren Murthy, Ryan Jackson, Yang Liu Verified, Alan Ashworth Verified, Jennifer Doudna, Min Hyung Kang
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Nature
Verified
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
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Abstract Posterior fossa type A (PFA) ependymoma is an unusual infantile brain tumour with few known somatic mutations, thought to be driven by epigenetic mechanisms1. PFA ependymoma has a markedly higher incidence and worse prognosis in male children than in female children2. The mechanisms that underlie these sex differences are at present unknown. Here we show that the cellular hierarchy of PFA ependymoma is less differentiated in male individuals than it is in female individuals.
By Winnie Ong, Alexandra Rasnitsyn, Ricardo Gonzalez, Ricardo González, Rodrigo Gutierrez, Rodrigo Gutiérrez Verified, Polina Balin, Amr M. Saadeldin, Xiaochong Wu, Maria C. Vladoiu, Vicente López, Fernando Gonzalez-Salinas, Navneesh Yadav, Dinesh Mohanakrishnan, Hinda Najem, Sebastian Pacheco, Kaitlin Kharas, Cory M Richman, David Przelicki, EVAN WANG, Haipeng Su, Rachel Curry Verified, Runze Yang, Michelle Kameda-Smith, David Scott, Zaili Luo, Mingyang Xia, Namal Abeysundara, Anders Erickson, Ncedile Mankahla, Chu Pan, Raul Climent Suarez, Raúl Tello Suarez, Raúl A. Suárez, Ning Huang, Yihao Wu, Hao Wang, Tajana Douglas, Jonelle G. Pallota, Steven Hebert, Heather Whetstone, Hassaan Maan, Hussein Lakkis, Juyeun Lee, Sadeesh K. Ramakrishnan, Yanxin Pei, Yujie Tang, Frank Lin, Guillermo Aldave, Marco Gallo, Robert M. Friedlander, Faiyaz Notta, Laura Donovan, Murali Chintagumpala, Bo Wang, Yun Li Verified, Zhaolei Zhang, Ying Mao, Wei Hua, Charles G. Eberhart, Calixto-Hope G. Lucas, Sriram Venneti, Poul H Sorensen, Alberto Delaidelli, Wenhao Zhou, Jason Kirk Verified, Dean Tang, Tao Jiang, Hailong Liu, Justin D Lathia, Hiromichi Suzuki, Jeremy Rich, Lincoln D. Stein, Nada Jabado, Vijay Ramaswamy, Q. Lu, Amy B. Heimberger, Craig Daniels, Kulandaimanuvel Antony Michealraj, Claudia L. Kleinman, Bryn Livingston, Krystin Mantione
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Nature
Verified
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