Jianyin Long
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The Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Morphology and Progression of Diabetic Kidney Disease
Keywords Animals, Mice, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Diabetes Mellitus, Diabetic Nephropathies, Gene Expression Regulation, Kidney, Lipidomics, Transcription Factors, lipid metabolism, mitochondria, phospholipid, kidney metabolism, diabetic nephropathy Abstract A substantial body of evidence has established the contributions of both mitochondrial dynamics and lipid metabolism to the pathogenesis of diabetic kidney disease (DKD).
Role for Carbohydrate Response Element-Binding Protein (ChREBP) in High Glucose-Mediated Repression of Long Noncoding RNA Tug1
Keywords Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cell Line, Tumor, Gene Expression Regulation, Glucose, Histone Deacetylase 1, Humans, Mice, Podocytes, RNA, Long Noncoding, Repressor Proteins, Transcription, Genetic Abstract Long noncoding RNAs (lncRNAs) have been shown to play key roles in a variety of biological activities of the cell.
"Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropa" by Juan D Coellar, Jianyin Long et al.
Keywords Diabetic Nephropathies, Humans, Kidney, RNA, Long Noncoding, RNA, non-coding RNA, lncRNA, Kidneys, Diabetic Nephropathy Abstract Recent advances in large-scale RNA sequencing and genome-wide profiling projects have unraveled a heterogeneous group of RNAs, collectively known as long noncoding RNAs (lncRNAs), which play central roles in many diverse biological processes.
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