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Jin Hwi Park on Muck Rack

Jin Hwi Park

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YH42946, a novel and selective tyrosine kinase inhibitor, demonstrates potent antitumor activity against EGFR exon 20 insertion mutations and HER2 alterations in NSCLC

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By Dong Kwon Kim, Min Hong, Kwangho Lee, Jii Bum Lee, Byoung Chul Cho, Yun Joo Joo, Hyeon Bin Cho, Jin Hwi Park, Eunjeong Jeong, Sun Min Lim
| Nature Verified
Abstract EGFR exon 20 insertion mutations and HER2 alterations are oncogenic drivers in non–small cell lung cancer (NSCLC) with limited therapeutic options. YH42946 is an orally available tyrosine kinase inhibitor designed to selectively target these alterations while sparing EGFR wild-type. Here, we evaluated the in vitro and in vivo antitumor efficacy of YH42946.
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