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Articles by Jing An
Integrated time-series multi-omics reveals temporal reprogramming and inter-organ divergence in diabetic cardiorenal syndrome
Abstract Diabetes induces progressive transcriptional reprogramming in the heart and kidney, yet their tissue-specific temporal dynamics and cellular mechanisms remain incompletely understood. In this study, we employed a longitudinal design with dense sampling intervals, performing time-series bulk RNA-seq on heart and kidney tissues across six bi-weekly intervals from Control, high-fat diet (HF), diabetes (DM), and insulin-treated (INS) mice (n=38 total samples).
Efficacy of combination treatment by ustekinumab and exclusive enteral nutrition in adult patients with moderate-to-severe Crohn’s disease
Abstract Despite growing evidence affirming the therapeutic efficacy of ustekinumab (UST) in the treatment of Crohn’s disease (CD), optimizing clinical responses to this biologic continued to pose a significant challenge in clinical practice. From October 2020 to September 2024, a retrospective study was conducted on 114 patients with moderately-to-severely active CD who received optimized ustekinumab by 2 initial intravenous doses in three inflammatory bowel disease (IBD) centers.
Multidimensional regulation of hepatic macrophages in chronic liver disease: from metabolic reprogramming to intercellular and interorgan crosstalk
Abstract Chronic liver diseases (CLDs), including metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD, viral hepatitis, liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC)), impose enormous global public health burdens. Hepatic macrophages act as core orchestrators governing the initiation and progression of all CLD subtypes.
Effects of repeated-sprint training on intermittent aerobic endurance, anaerobic performance, and repeated-sprint ability in female collegiate basketball players
Abstract Objective: This study examined the effects of a 6-week repeated-sprint training (RST) intervention on intermittent aerobic endurance, anaerobic power, and repeated-sprint ability (RSA) in female collegiate basketball players compared with duration-matched continuous running.
Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC
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ArticleVolume 45, Issue 8117797Open access Affiliations & Notes 1State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, School of Convergence Medicine, Zhengzhou University, Zhengzhou, China 2Aging Decoding and Regeneration Institute, School of Life Sciences, Zhengzhou University, Zhengzhou, China 3Zhengzhou Key Laboratory of Lipid Metabolism and Precision Diagnosis & Treatment in Oncology, Oncology...
By Yanmei Yang, Peixian Li, Liangbo Zhao, Lingwei Zhang, Hong Chang Chen, Hao Xing, Pingping Zhu, Jing An, Luyun He, Shuiling Jin, Nian Liu Verified, Shuaixi Yang, Xiao Sun, Benyu Liu
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Cell Reports
Verified
Digital mood phenotyping predicts short- and long-term suicidal ideation across a two-year timescale
Abstract Suicide risk is disproportionately elevated among sexual and gender minority (SGM) individuals. Identifying time-varying risk states is critical for prevention, yet conventional assessments may not adequately capture mood fluctuations that precede suicidal ideation (SI). In this study, we explored whether ecological momentary assessment (EMA) of mood could capture short-term vulnerability and whether emotion-based subtyping could provide longer-term risk stratification.
Interoception in self-harm and suicide: a scoping review and meta-analysis
Abstract Interoception, the capacity to sense and interpret internal bodily signals, has been recognized as relevant to self-harm and suicide, but these associations and their dimensional specificity have not been quantitatively synthesized.
Infection-driven proliferative phase impairment in chronic wounds: a mechanistic framework for precision regenerative therapy
Abstract Chronic wounds represent a major clinical challenge characterized by persistent failure of tissue repair, a phenomenon that cannot be fully explained by infection and inflammation alone. Emerging evidence indicates that wound-associated microbial communities establish stable pathogenic ecosystems that specifically disrupt the proliferative phase of healing, the critical stage responsible for cellular expansion, angiogenesis, and extracellular matrix reconstruction.
Assessing spatial accessibility of rabies post-exposure prophylaxis clinics in Gansu Province, China
Abstract Objective: To understand the current status of rabies post-exposure prophylaxis (PEP) clinic construction in Gansu Province and analyze the distribution of rabies PEP clinics across the province. To evaluate residents’ geographic accessibility to rabies PEP clinics, to provide a sound basis for the rational allocation of medical resources related to rabies PEP. Methods: Address information and service type data of rabies PEP clinics in Gansu Province in 2024 were collected.
High-Order Numerical Approximation Based on the Ciarlet-Raviart Mixed Scheme for Fourth-Order Problem in a Complex Domain
M.Zheng, J.Zheng, and J.An, “High-Order Numerical Approximation Based on the Ciarlet-Raviart Mixed Scheme for Fourth-Order Problem in a Complex Domain,” Mathematical Methods in the Applied Sciences (2026): 1–25, https://doi.org/10.1002/mma.70774. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The authors have nothing to report. References 1, Foundations and Applications of the Hybrid Finite Element Method (Science Press, 2006).
Decade-long warming accelerates antibiotic resistance in grassland soils
Abstract Soils are critical reservoirs of antibiotic-resistance genes (ARGs)1,2, which are strongly shaped by microbial interactions and environmental conditions and are therefore highly sensitive to disturbance2,3,4,5,6. Although climate warming is recognized as one of the most significant disturbances to microbial communities and their functions7,8,9,10, its impacts on soil resistomes remain poorly understood.
Left Ventricular Ejection Fraction Reporting Variability and Artificial intelligence-Assisted Reproducibility: A Multicenter Analysis
Keywords Cardiovascular magnetic resonance Artificial intelligence Left ventricular ejection fraction Reliability Reproducibility Abbreviations AI (artificial intelligence) CMR (cardiac magnetic resonance) LVEF (left ventricular ejection fraction) LVEDV (left ventricular end-diastolic volume) LVESV (left ventricular end-systolic volume) LVM (left ventricular mass) RVEDV (right ventricular end-diastolic volume) RVESV (right ventricular end-systolic volume) RVEF (right ventricular ejection...
Distribution Characteristics and Cross‐Media Transmission of Tetracycline Resistance Genes in Black Soil Farmland and Vegetable Under Manure Fertilization
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data will be made available on request. References , , , and . 2015. “Antibiotic Contamination in Animal Manure, Soil, and Sewage Sludge in Shenyang, Northeast China.” Environment and Earth Science 74, no. 6: 5077–5086. , , , , , and . 2019. “Distribution of Antibiotic Resistance Genes in Soils and Crops.
Effects of supplementation with Bacillus subtilis peptide on growth performance, intestinal barrier and caecal microbiota metabolism in broilers
Abstract This study assessed Bacillus subtilis (B. subtilis) peptide as broiler feed additives. A total of 240 one-day-old male broilers were assigned to four groups (six replicates of 10 broilers) for 42 days. The control group was administered a basic diet, whereas the treatment groups got the basal food augmented with B. subtilis peptide at doses of 100, 200, or 300 mg/kg (low, medium, or high dose). The growth performance, intestinal mucosal morphology, immunity, and microbiota were measured.
Burden, trends and projections of liver cancer in China and G20 countries: a comparative study based on the global burden of disease database 2021
Introduction Liver cancer is one of the most prevalent malignancies globally and poses a substantial threat to public health worldwide. Ranked as the sixth most common cancer in terms of incidence and the third leading cause of cancer mortality (1), it represents a major global health challenge associated with considerable disease burden, particularly in Asia and China. Approximately 75% of liver cancer cases occur in Asia, with China accounting for over 50% of the global total (2, 3).
Therapeutic Drug Monitoring for Individualized Antidepressant Treatmen
Back to Journals » Drug Design, Development and Therapy » Volume 19 Authors Li Y, Du X, An J, Wu H Received 10 September 2025 Accepted for publication 18 December 2025 Published 24 December 2025 Volume 2025:19 Pages 11585—11608 DOI https://doi.org/10.2147/DDDT.S566716 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Yan Zhu Yumeng Li,1,2 Xiaoyu Du,1,2 Jing An,1,2 Huizhen Wu1,2 1Graduate School of Hebei...
The effects of 8 weeks of sprint interval training on repeated sprinting and specialized ability in college volleyball players
Loading metrics Open Access Peer-reviewed Research Article Citation: Wei C, An J, Zhou L (2025) The effects of 8 weeks of sprint interval training on repeated sprinting and specialized ability in college volleyball players. PLoS One 20(7): e0327561. https://doi.org/10.1371/journal.pone.0327561 Editor: Esedullah Akaras, Erzurum Technical University: Erzurum Teknik Universitesi, TÜRKIYE Received: April 1, 2025; Accepted: June 17, 2025; Published: July 16, 2025 Copyright: © 2025 Wei et al.
Insulin‐Like Growth Factor Binding Protein 2 Drives Neurodegeneration in Parkinson's Disease: Insights From In Vivo and In Vitro Studies
6-OHDA 6-hyhydroxydopamine ATP adenosine triphosphate CCK-8 cell counting kit-8 DEGs differentially expressed genes GSH-Px glutathione peroxidase IGF-1 insulin-like growth factor-1 IGFBP2 insulin-like growth factor binding protein 2 IHC immunohistochemistry MDA malondialdehyde mRNA-seq mRNA sequencing PD Parkinson's disease rIGF-1 recombinant IGF-1 rIGFBP2 recombinant IGFBP2 ROS reactive oxygen species RT-qPCR reverse transcription quantitative PCR SNpc substantia nigra pars compacta SOD...
Spectral Galerkin Approximation and Error Analysis Based on a Mixed Scheme for Fourth‐Order Problems in Complex Regions
Conflicts of Interest The authors declare no conflicts of interest. References 1 and , Spectral and High-Order Methods With Applications (Beijing: Science Press, 2006). 2, , and , Spectral Methods: Algorithms, Analysis and Applications (Berlin, Heidelberg: Springer Science and Business Media, 2011). 3 and , “Error Estimates of Spectral Legendre-Galerkin Methods for the Fourth-Order Equation in One Dimension,” Applied Mathematics and Computation 268 (2015): 1217–1226.
Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway
Loading metrics Open Access Peer-reviewed Research Article Citation: Liu K, An J, Zhang J, Zhao J, Sun P, He Z (2024) Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway. PLoS ONE 19(10): e0311824.
Genome-Wide Scan for Copy Number Variations in Chinese Merino Sheep Based on Ovine High-Density 600K SNP Arrays
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Stability analysis and error estimation based on difference spectral approximation for Allen-Cahn equation in a circular domain
REFERENCES 1 and , A microscopic theory for antiphase boundary motion and its application to antiphase domain coarsening, Acta Metall. Mater. 27 (1979), 1085–1095. 2, , and , A new class of efficient and robust energy stable schemes for gradient flows, SIAM Rev. 61 (2019), 474–506. 3 and , Applications of semi-implicit Fourier-spectral method to phase-field equations, Comput. Phys. Comm. 108 (1998), 147–158.
Infections associated with CAR‐T cell therapy in patients with relapsed refractory multiple myeloma: Risks and prevention strategies
1 INTRODUCTION Multiple myeloma (MM) is a common malignant tumor in clinical practice.1 Over recent decades, the survival of patients with MM has significantly improved with the widespread use of anti-MM agents.2 Chimeric antigen receptor (CAR) T-cell therapy has also provided a new regimen for the treatment of relapsed refractory MM (RRMM), showing substantial efficacy with controllable adverse reactions.3-5 The US Food and Drug Administration has approved the CAR-T cell products...
Soil condition determines how crop residues affect soil compressive characteristics
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper. REFERENCES , , & (2014). Assessing confined and semi-confined compression curves of highly calcareous remolded soil amended with farmyard manure. Journal of Terramechanics, 53, 75–82. , & (1998). The relationship among the pre-compaction stress, volumetric water content and initial dry bulk density of soil.
Photocontrolled heterojunctions constructed from holmium single atom modified Mg1.2Ti1.8O5/g-C3N4 with enhanced photocatalytic CO2 conversion
Photocontrolled heterojunctions constructed from holmium single atom modified Mg1.2Ti1.8O5/g-C3N4 with enhanced photocatalytic CO2 conversion† Photocontrolled composites are worth studying because they exhibit different types of heterojunctions and tunable characteristics under different wavelengths of light.
A Novel Perspective on Enhancing Photocatalytic Performance through the Synergistic Effect of Nd Single Atoms and Heterostructures
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202400618-sup-0001-SuppMat.pdf1.7 MB Supporting Information References 1, , , , , , , , , , Angew. Chem., Int. Ed. 2022, 61, 8. 2, , , Carbon Energy 2022, 4, 1021. 3, , , , Adv. Mater. 2023, 5, 2304713. 4, , , , Angew. Chem., Int. Ed. 2021, 133, 21340. 5, , , , , , , , Adv. Mater. 2022, 34, 2204865. 6, , , , , , , Nat. Rev. Methods Primers. 2023, 3, 21. 7, , , , , , , Adv. Mater. 2021, 33, 2102690.
Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma - Nature Communications
Abstract Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM chemoresistance and hypermutation are unknown.
Discrete Element Method-Multibody Dynamics Coupling Simulation and Experiment of Rotary Tillage and Ridging Process for Chili Pepper Cultivation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Effects of biotin and coated cobalamin on lactation performance, nutrient digestion and rumen fermentation in Holstein dairy cows
CONFLICT OF INTEREST STATEMENT The authors declare that no conflicts of interest exist. REFERENCES , , , , , & (2002). Microbial status and rumen enzyme profile of crossbred calves fed on different microbial feed additives. Letters in Applied Microbiology, 34, 329–336. https://doi.org/10.1046/j.1472-765X.2002.01092.x , , , & (2013). Effects of cobalt supplementation and vitamin B12 injections on lactation performance and metabolism of Holstein dairy cows. Journal of Dairy Science, 96, 1755–1768.
Single‐cell RNA sequencing reveals immune microenvironment of small cell lung cancer‐associated malignant pleural effusion
INTRODUCTION Patients with small cell lung cancer (SCLC) have a very poor prognosis, particularly those at an advanced stage of disease.1, 2 The first-line treatment for small cell lung cancer is chemotherapy, but tumor cells are prone to rapidly transitioning from being chemotherapy sensitive to chemotherapy resistant.3-6 Current studies have reported that immunotherapies for the treatment of small cell lung cancer have shown promising results.7-11 Heterogeneity and the immune...
The multiple roles of rare earth elements in the field of photocatalysis
The multiple roles of rare earth elements in the field of photocatalysis When illuminated by light, different electron transitions occur within the energy levels due to the unique 4f energy level structure of rare earth elements. If rare earth elements are introduced into clean and sustainable photocatalysis technology, the electronic transitions in the energy level structure of the catalyst may change, forming a unique reaction mechanism and producing excellent catalytic performance.
The Ecological Healthcare Benefits and Influences of Plant Communities in Urban Wetland Parks
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Efficacy and Safety of Pericapsular Nerve Group Block for Hip Fracture Surgery under Spinal Anesthesia: A Meta-Analysis
Objective. To evaluate the effectiveness and safety of pericapsular nerve group (PENG) block for hip fracture surgery under spinal anesthesia. Methods. This meta-analysis was registered on INPLASY (INPLASY202270005). PubMed, Embase, Cochrane, CNKI, and Wanfang databases were searched to collect the randomized controlled trials of the PENG block applied to hip fracture surgery in the setting of spinal anesthesia, with the search period from inception to 1 May 2023.
Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma
Abstract Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM chemoresistance and hypermutation are unknown.
A Legendre spectral‐Galerkin method for fourth‐order problems in cylindrical regions
CONFLICT OF INTEREST STATEMENT The authors declare that they have no competing interests. REFERENCES 1, , and , Spectral-Galerkin approximation and optimal error estimate for biharmonic eigenvalue problems in circular/spherical/elliptical domains, Numer. Algorithms 84 (2020), 427–455. 2 and , Spectral approximation to a transmission eigenvalue problem and its applications to an inverse problem, Comput. Math. Appl. 69 (2015), no. 10, 1132–1143.
Transportation and Reserve of Emergency Medical Supplies during Public Health Events
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by * and School of Management, Nanjing University of Posts and Telecommunications, Nanjing 210003, China * Author to whom correspondence should be addressed. Appl. Sci.
The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development - Communications Biology
Abstract Maintaining stable and transient quiescence in differentiated and stem cells, respectively, requires repression of the cell cycle. The plant RETINOBLASTOMA-RELATED (RBR) has been implicated in stem cell maintenance, presumably by forming repressor complexes with E2F transcription factors. Surprisingly we find that mutations in all three canonical E2Fs do not hinder the cell cycle, but similarly to RBR silencing, result in hyperplasia.
Elderly Fall Detection Based on GCN-LSTM Multi-Task Learning Using Nursing Aids Integrated with Multi-Array Flexible Tactile Sensors
2.2. Analysis of Plantar Tactile Sensor Layout The distribution of plantar pressure in different regions reflects the human body’s movement state. The primary functions of the human foot are to support the body, cushion and absorb impact forces, facilitate movement, and maintain stability [29,30,31]. As pressure sensors have limited sensing areas, it is crucial to maximize the collection of plantar pressure information.
Effects of Cadmium Stress on Carbon Sequestration and Oxygen Release Characteristics in A Landscaping Hyperaccumulator-Lonicera japonica Thunb.
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Foods | Free Full-Text | Detection of Specific Volatile Organic Compounds in Tribolium castaneum (Herbst) by Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Shaoyun Han 1, Ke He 1, Jing An 1, Mengmeng Qiao 1, Runhui Ke 2, Xiao Wang 2, Yang Xu 1,* and Xiuying Tang 1 1 College of Engineering, China Agricultural University, Beijing 100083, China 2 Sinolight Inspection& Certification Co., Ltd., Beijing 100083, China * Author to whom correspondence should be addressed.
Effects of Different Proteases on Protein Digestion In Vitro and In Vivo and Growth Performance of Broilers Fed Corn–Soybean Meal Diets
1. Introduction The digestion and utilization of dietary nutrients by broilers can be fully considered in combination with their physiological structure, gastrointestinal digestion and absorption characteristics and dietary structure characteristics [1,2,3]. After digestion of feed nutrients in the crop and stomach of broilers, the chyme is transferred into the small intestine to continue digestion.
Jointly Depleting Glutathione Based on Self‐Assembled Nanomicelles for Enhancing Photodynamic Therapy
Graphical Abstract A new strategy of jointly depleting GSH is proposed to enhance the therapeutic effect of PDT by preparing a nanomicelle by self-assembly method from GSH-activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS. Abstract Photodynamic therapy (PDT) is one common ROS-generating therapeutic method with high tumor selectivity and low side effects. But the GSH-upregulation often alleviates its therapeutic efficiency.
Jointly Depleting Glutathione based on Self‐assembled Nanomicelles for Enhancing Photodynamic Therapy
Abstract Photodynamic therapy (PDT) is one common ROS-generating therapeutic method with high tumor selectivity and low side effects. But the GSH-upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self-assembly method from GSH-activated photosensitizer DMT, curcumin and amphiphilic polymer TPGS.
Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation - Nature Communications
Abstract Zika virus (ZIKV) is a potential threat to male reproductive health but the mechanisms underlying its influence on testes during ZIKV infection remain obscure. To address this question, we perform single-cell RNA sequencing using testes from ZIKV-infected mice.
Discrimination of Inner Injury of Korla Fragrant Pear Based on Multi-Electrical Parameters
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Jing An 1,2, Xiuzhi Luo 1, Lijian Xiong 1, Xiuying Tang 1,* and Haipeng Lan 2 1 College of Engineering, China Agricultural University, Beijing 100083, China 2 College of Mechanical and Electrical Engineering, Tarim University, Alar 843300, China * Author to whom correspondence should be addressed.
Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method
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The K/HDEL receptor does not recycle but instead acts as a Golgi-gatekeeper - Nature Communications
Abstract Accurately measuring the ability of the K/HDEL receptor (ERD2) to retain the ER cargo Amy-HDEL has questioned earlier results on which the popular receptor recycling model is based upon. Here we demonstrate that ERD2 Golgi-retention, rather than fast ER export supports its function. Ligand-induced ERD2 redistribution is only observed when the C-terminus is masked or mutated, compromising the signal that prevents Golgi-to-ER transport of the receptor.
Incidence and Prognostic Role of Pleural Effusion in Patients with Pulmonary Embolism: A Systematic Review and Meta-Analysis
Font Type: Arial Georgia Verdana Line Spacing: Column Width: Open AccessSystematic Review by Ping Li †, Jing An †, Shuyan Wang , Xueru Hu , Tingting Zeng , Chun Wan , Yongchun Shen * and Tao Wang * Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China * Authors to whom correspondence should be addressed.
Molecules | Free Full-Text | Niobium Complexes Supported by Chalcogen-Bridged [OEO]-Type Bis(phenolate) Ligands (E = S, Se): Synthesis, Characterization, and Phenylacetylene Polymerization
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