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Comparison of efficacy and safety of systemic glucocorticoids and Nefecon in IgA nephropathy patients: a real-world retrospective cohort study
Abstract Background: This study compared the effectiveness and safety profiles of systemic glucocorticoids (sGCs) and Nefecon in the treatment of patients with immunoglobulin A nephropathy (IgAN). Methods: Patients with IgAN who had an estimated glomerular filtration rate (eGFR) ≥ 15 mL/min/1.73 m² and were treated with sGCs or Nefecon were included.
Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq
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Abstract T/B cell receptors (T/BCR), coordinating antigen-targeting immune response, play crucial roles in anti-tumor immune response. Tracking T and B cell clonal evolution in situ at single-cell resolution is essential for understanding the adaptive immune responses.
By Xiaojuan Zhan, Yang Zhang, Zhong Liu, Chengwu Liu, Yanying Guo, Yi Liu, Wenwen Zhou, Yixin Yan, Hui Zeng, Xuan Dong, Xiaoyu Chen, Rong Ma, Fan Zhu, Xubin Zheng, Xinxing Li, Sen Hou, Zhidong Gao, Jinwen Yin, Francis Chan, Qin Wu, Senyi Deng, Yin Yao, Shengbao Suo, Chuanyu Liu, Longqi Liu, Xun Xu, Yong Hou, HaoRan Tao, Yuliang Dong, Tao Zeng, Hanyong Sun, Li Zuo, Hua Wang, Xin Zhe Liu, Zhifang Wu, Jingying Zhou, Zexian Zeng, Yu Feng, Mengye Huang, Yingqi Dong, Haohang Yang, Xinlei Ai
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Nature
Verified
Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling
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Keywords hepatocellular carcinoma immune-checkpoint blockade TREM2 efferocytosis lipid-associated macrophages fatty acid metabolism Introduction Tumor cells reprogram their metabolism in response to diverse environmental conditions.
By Zhixian Liang, Xiaohang Long, Zhewen Xiong, Patrick Wong, Siyuan Huang, Siyun Chen, Yiling Zhang, Lingyun Zhang, Haoran Wu, Hui Yue, Zihui Zhao, Yalin Tu, Baoyi Yin, Weiqin Yang, Jing Wang, Shufen Chen, Yuk Wah Tsang, Chengpeng Zhong, Xiaoyu LIU, Lipeng Ding, Jiahuan Lu, Yan Liu, Yaxian Wang, Yingnan Lin, Jianxin Liang, Hannah Xiaoyan Hui, Jingying Zhou, Ka-Fai To, Thomas Braun, Joseph Jao-Yiu Sung, Stephen Chan, Alfred Sze-Lok Cheng, Chunning Leung, Jianquan Cao, Xuerao Zhang, Willis Wai-Yiu Si-Tou, Weida Ren, Joaquim Si-Long Vong
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Cell Press
Verified
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