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Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq
Abstract T/B cell receptors (T/BCR), coordinating antigen-targeting immune response, play crucial roles in anti-tumor immune response. Tracking T and B cell clonal evolution in situ at single-cell resolution is essential for understanding the adaptive immune responses.
Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling
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Keywords hepatocellular carcinoma immune-checkpoint blockade TREM2 efferocytosis lipid-associated macrophages fatty acid metabolism Introduction Tumor cells reprogram their metabolism in response to diverse environmental conditions.
By Zhixian Liang, Xiaohang Long, Zhewen Xiong, Patrick Wong, Siyuan Huang, Siyun Chen, Yiling Zhang, Lingyun Zhang, Haoran Wu, Hui Yue, Zihui Zhao, Yalin Tu, Baoyi Yin, Weiqin Yang, Jing Wang, Shufen Chen, Yuk Wah Tsang, Chengpeng Zhong, Xiaoyu LIU, Lipeng Ding, Jiahuan Lu, Yan Liu, Yaxian Wang, Yingnan Lin, Jianxin Liang, Hannah Xiaoyan Hui, Jingying Zhou, Ka-Fai To, Thomas Braun, Joseph Jao-Yiu Sung, Stephen Chan, Alfred Sze-Lok Cheng, Chunning Leung, Jianquan Cao, Xuerao Zhang, Willis Wai-Yiu Si-Tou, Weida Ren, Joaquim Si-Long Vong
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Cell Press
Verified
Risk factors for progression to bronchitis or pneumonia in hospitalized children with human rhinovirus infection: a retrospective cohort study using machine learning
Abstract Background: Human rhinovirus (HRV) is a leading cause of acute respiratory infections and hospitalization in children. However, risk factors for progression to bronchitis vs. pneumonia remain incompletely characterized. Objective: This study aimed to identify and distinguish independent predictors for these outcomes using a machine learning approach.
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