Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Jinjun Wu
Alphaviral non-structural protein-host RBP co-condensation as a mechanism to sustain virus replication
ArticleVolume 86, Issue 12p2390-2409.e17 Affiliations & Notes 1Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China 2School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China 3Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA 4Howard Hughes Medical Institute, Chevy Chase, MD, USA 5Life Sciences Institute, Zhejiang University, Hangzhou, China Article Info Publication History: Received April 16, 2025;...
ASPL couples the assembly of stress granules with their VCP-mediated disassembly
Abstract Stress granules (SGs) are dynamic RNA-protein assemblies that form in response to cellular stress and must be efficiently disassembled to restore normal cell function. Valosin-containing protein (VCP), an enzyme implicated in neurodegenerative diseases, is essential for SG disassembly, but whether and how this process is coordinated with SG assembly remains unclear.
In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes - Nature Chemical Biology
Abstract Profiling the protein interactome of specific RNA loci aids in understanding the molecular mechanisms of regulatory RNA. However, current RNA-centric methods have sufficient space for improvement in terms of efficiency and biocompatibility.
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency
Abstract Nuclear speckles are nuclear membraneless organelles in higher eukaryotic cells playing a vital role in gene expression. Using an in situ reverse transcription–based sequencing method, we study nuclear speckle–associated human transcripts. Our data indicate the existence of three gene groups whose transcripts demonstrate different speckle localization properties: stably enriched in nuclear speckles, transiently enriched in speckles at the pre–messenger RNA stage, and not enriched.
Bearing Capacity and Reinforced Mechanisms of Horizontal-Vertical Geogrid in Foundations: PFC3D Study
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency
Abstract Nuclear speckles, a type of membraneless nuclear organelle in higher eukaryotic cells, play a vital role in gene expression regulation. Using the reverse transcription-based RNA-binding protein binding sites sequencing (ARTR-seq) method, we study human transcripts associated with nuclear speckles.
Salvianolic Acid B Significantly Suppresses the Migration of Melanoma Cells via Direct Interaction with β-Actin
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
KARR-seq reveals cellular higher-order RNA structures and RNA–RNA interactions - Nature Biotechnology
Abstract RNA fate and function are affected by their structures and interactomes. However, how RNA and RNA-binding proteins (RBPs) assemble into higher-order structures and how RNA molecules may interact with each other to facilitate functions remain largely unknown.
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing - Nature Methods
Abstract RNA-binding proteins (RBPs) regulate diverse cellular processes by dynamically interacting with RNA targets. However, effective methods to capture both stable and transient interactions between RBPs and their RNA targets are still lacking, especially when the interaction is dynamic or samples are limited.
Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats
1 Introduction Diabetes mellitus (DM) is a chronic systemic metabolic disorder caused by combination of genetic and environmental factors over an extended period of time (Cole and Florez, 2020). Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are two major forms of DM, primarily triggered by pancreatic beta cell dysfunction, insulin secretion deficiency and insulin resistance (Eizirik et al., 2020).
Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
1 Introduction Colorectal cancer (CRC) ranks third among the globally most prevalent cancers, in terms of incidence and mortality (Sheng et al., 2020). The morbidity and mortality of CRC are consistently increasing, which poses a serious threat to the general population’s health (Jian et al., 2020).
CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2
This article is Open Access Please wait while we load your content... Something went wrong. Try again?
Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9
Abstract Protein coronae formed with nanoparticles confer several useful properties. However, the non‐specific nature of protein corona formation makes it difficult to deliver specific proteins for therapeutic applications. Herein, we report on the construction of a new type of protein corona, termed binding‐mediated protein corona. This new corona enables the efficient and controllable delivery of functional proteins, which is otherwise challenging for conventional protein coronae.
Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase
Highlights • Bacterial EndoV binds 1 and 2 nt surrounding an inosine and repairs DNA • Eukaryotic EndoV binds 2–4 and 8 bp RNA before and after an inosine, respectively • RNA specificity of eukaryotic EndoV is determined by a few flexible loops • RNA cleavage by mouse EndoV requires a third transiently bound Mg 2+ or Mn 2+ Summary Endonuclease V (EndoV) cleaves the second phosphodiester bond 3′ to a deaminated adenosine (inosine).
Detecting 5-Methylcytosine Using an Enzyme-free DNA Strand Exchange Reaction Without Pretreatment Under Physiological Conditions
We welcome your comments for improvement of this site and our services. Please enter the characters in the box below as you see them. Thank you for helping us improve our site.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Jinjun
Contact Jinjun, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack