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Effects and mechanisms of transcutaneous auricular vagus nerve stimulation on post-stroke cognitive impairment in animal studies: a systematic review and meta-analysis
Abstract Background: Post-stroke cognitive impairment (PSCI) substantially undermines rehabilitation adherence and poses a major obstacle to functional recovery. Transcutaneous auricular vagus nerve stimulation (taVNS), a noninvasive neuromodulation technique, has the potential to improve cognitive function, as demonstrated in various clinical and preclinical studies.
Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary The treatment of glioblastoma (GBM) is constrained by limitations in surgical precision during resection and limited spatial sensitivity of clinical imaging techniques. Here, Shangguan et al.
Synthesis of selective BCL-XL PROTAC and potent antitumor activity in glioblastoma
Keywords glioblastoma glioblastoma stem cells proteolysis-targeting chimeras BCL-XL Introduction Glioblastoma (GBM), characterized as a rapidly growing and highly invasive malignancy, represents the most prevalent and lethal primary brain tumor, with a median survival of merely 14 months and a 2-year survival rate below 10%.1,2 Currently, the standard treatment regimen for GBM encompasses surgical resection, followed by radiation therapy and adjuvant temozolomide chemotherapy.3 Despite these...
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