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Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary The treatment of glioblastoma (GBM) is constrained by limitations in surgical precision during resection and limited spatial sensitivity of clinical imaging techniques. Here, Shangguan et al.
Abstract The cerebral cortex is organized along a dominant sensorimotor-to-association (S–A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas forming distributed networks that support abstract cognition at the other1,2,3,4,5,6,7,8,9,10,11. The developmental mechanisms shaping this axis remain unclear9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24.
Abstract Mammals have evolved a more complex brain, exemplified by the transformation of the single-layer dorsal cortex of excitatory projection neurons (ExNs) in ancestors into a multilayered cerebral neocortex1,2,3,4 enriched with diverse intratelencephalic and extratelencephalic ExN subtypes5,6,7, thereby establishing specialized projection systems that enhance brain connectivity and functionality5,6,7,8.
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