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Joaquim Ollé López on Muck Rack

Joaquim Ollé López

As seen in: Cell Press
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Maintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatin

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By Rikke Rejnholdt Jensen, Valentin Flury, Jeroen van den Berg, Jonathan Humbert, Nicolas Alcaraz, Simai Wang, Hannah Richter, Marty G. Yang, Qian Du, Alexander van Oudenaarden, Vijay Ramani, Nils Krietenstein, Anja Groth, R. Ciaran MacKenzie Frater, Joaquim Ollé López, Anton Bournonville
| Cell Press Verified
Results We used the dTAG system65 to generate a mESC model for acute SPT16 depletion. SPT16 is the primary subunit responsible for H3-H4 engagement in recent structures.45,47 One hour of dTAG treatment resulted in strong depletion of SPT16 (Figures 1A and S1A). SPT16-depleted (dSPT16) cells showed reduced viability by 6 h, and most cells died within 24 h (Figure 1B), indicating that mESCs do not tolerate loss of FACT.
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