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Joel B. Heim on Muck Rack

Joel B. Heim

As seen in: BioRxiv
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Articles

Structural and functional characterization of integrin a5-targeting antibodies for anti-angiogenic therapy

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By Adam Nguyen, Joel B. Heim, Gabriele Cordara, Matthew Chan
| BioRxiv
Abstract Integrins are a large family of heterodimeric receptors important for cell adhesion and signaling. Integrin a5b1, also known as the fibronectin receptor, is a key mediator of angiogenesis and its dysregulation is associated with tumor proliferation, progression, and metastasis. Despite numerous efforts, a5b1-targeting therapeutics have been unsuccessful in large part due to efficacy and off-target effects.
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FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis

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By Saranya P. Wyles, Joel B. Heim, Cera A. McDonald
| PLOS
To study the phenotype of mice expressing FAK Y397F or Y397E during development and in adult tissue, we targeted exon 15 of the murine FAK gene by homologous recombination in embryonic stem (ES) cells. Positive ES cell clones of each mutation were injected into blastocysts to establish the mutant knock-in (KI) mouse strains (KI neo+ ) [ 10 ].
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